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    Serinc3 serine incorporator 3 [ Mus musculus (house mouse) ]

    Gene ID: 26943, updated on 26-Sep-2022

    Summary

    Official Symbol
    Serinc3provided by MGI
    Official Full Name
    serine incorporator 3provided by MGI
    Primary source
    MGI:MGI:1349457
    See related
    Ensembl:ENSMUSG00000017707 AllianceGenome:MGI:1349457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tde1; AIGP1; TMS-1; DIFF33
    Summary
    Acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including adrenal medulla; craniocervical region bone; ganglia; liver lobe; and thymus primordium. Orthologous to human SERINC3 (serine incorporator 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 233.6), ovary adult (RPKM 192.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Serinc3 in Genome Data Viewer
    Location:
    2; 2 H3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163465193..163487071, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163623273..163645149, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Crx opposite strand transcript 1 pseudogene Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene protein kinase inhibitor, gamma Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine incorporator 3
    Names
    AIGP-1
    axotomy-induced glyco/Golgi protein 1
    axotomy-induced glycoprotein 1
    membrane protein TMS-1
    tumor differentially expressed 1
    tumor differentially expressed protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012032.4NP_036162.3  serine incorporator 3 precursor

      See identical proteins and their annotated locations for NP_036162.3

      Status: VALIDATED

      Source sequence(s)
      AK031101, AK128955, AK155921, BY012367
      Consensus CDS
      CCDS17013.1
      UniProtKB/Swiss-Prot
      Q91VN9, Q9QZI9
      UniProtKB/TrEMBL
      A0A8C6IED6
      Related
      ENSMUSP00000017851.4, ENSMUST00000017851.4
      Conserved Domains (1) summary
      pfam03348
      Location:16470
      Serinc; Serine incorporator (Serinc)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163465193..163487071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251672.2XP_030107532.1  serine incorporator 3 isoform X1

      Conserved Domains (1) summary
      pfam03348
      Location:9463
      Serinc; Serine incorporator (Serinc)
    2. XM_006499616.4XP_006499679.1  serine incorporator 3 isoform X2

      Conserved Domains (1) summary
      pfam03348
      Location:1415
      Serinc; Serine incorporator (Serinc)