Format

Send to:

Choose Destination
    • Showing Current items.

    Mprip myosin phosphatase Rho interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 26936, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mpripprovided by MGI
    Official Full Name
    myosin phosphatase Rho interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1349438
    See related
    Ensembl:ENSMUSG00000005417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Rh; p11; RIP3; C76423; Rhoip3; Gm34094; p116Rip; AA536749; AI647711; mKIAA0864; 9530046C02
    Annotation information
    Note: Mprip (Gene ID: 26936) and Ripk3 (Gene ID: 56532) share the RIP3 symbol/alias in common. RIP3 is a widely used alternative name for Ripk3 (Gene ID: 56532), which can be confused with Mprip (Gene ID: 26936), which also uses RIP3 as an alternative name. [05 Mar 2019]
    Expression
    Ubiquitous expression in lung adult (RPKM 20.1), testis adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mprip in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59552973..59671688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59662470..59780862)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (59475997..59594362)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor 225 Neighboring gene predicted gene, 33998 Neighboring gene RIKEN cDNA 1700007J10 gene Neighboring gene predicted gene, 51899 Neighboring gene phospholipase D family, member 6 Neighboring gene folliculin Neighboring gene predicted gene 16062

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC67316

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in maintenance of protein location in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin phosphatase Rho-interacting protein
    Names
    Rho interacting protein 3
    Rho-interacting protein 3 (p116RIP) (RIP3)
    p116 Rho interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368931.1NP_001355860.1  myosin phosphatase Rho-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596204
      Conserved Domains (6) summary
      TIGR00618
      Location:8951576
      sbcc; exonuclease SbcC
      COG1196
      Location:8951214
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:21332400
      PRK03918; chromosome segregation protein; Provisional
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:507608
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:18862240
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    2. NM_012027.2NP_036157.2  myosin phosphatase Rho-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_036157.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 3' coding region that causes a frameshift, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK158296, AL596204, BC049803, CJ130801
      Consensus CDS
      CCDS24775.1
      UniProtKB/Swiss-Prot
      P97434
      Related
      ENSMUSP00000112072.2, ENSMUST00000116371.8
      Conserved Domains (5) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:389490
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:389477
      PH; PH domain
      cl02488
      Location:737975
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl03951
      Location:638756
      CDC37_N; Cdc37 N terminal kinase binding
    3. NM_201245.3NP_957697.1  myosin phosphatase Rho-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_957697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AK158296, AL596204, CJ130801
      Consensus CDS
      CCDS24774.1
      UniProtKB/Swiss-Prot
      P97434
      Related
      ENSMUSP00000071914.7, ENSMUST00000072031.13
      Conserved Domains (5) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:389490
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:389477
      PH; PH domain
      cl02488
      Location:737975
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl03951
      Location:638756
      CDC37_N; Cdc37 N terminal kinase binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      59552973..59671688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314568.3XP_017170057.1  myosin phosphatase Rho-interacting protein isoform X1

      Conserved Domains (6) summary
      TIGR00618
      Location:8951576
      sbcc; exonuclease SbcC
      COG1196
      Location:8951214
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:21332400
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:507608
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:18862240
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    2. XM_030246039.2XP_030101899.1  myosin phosphatase Rho-interacting protein isoform X13

      Conserved Domains (4) summary
      COG4372
      Location:7951060
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:507608
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:9321227
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    3. XM_006533439.3XP_006533502.1  myosin phosphatase Rho-interacting protein isoform X16

      Related
      ENSMUSP00000119562.2, ENSMUST00000133861.8
      Conserved Domains (3) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:507608
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:7801090
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    4. XM_006533438.3XP_006533501.1  myosin phosphatase Rho-interacting protein isoform X15

      Conserved Domains (3) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:507608
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:7801090
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_036156726.1XP_036012619.1  myosin phosphatase Rho-interacting protein isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:8721191
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:728973
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17171
      Location:507585
      PH-like; Pleckstrin homology-like domain
    6. XM_006533428.3XP_006533491.1  myosin phosphatase Rho-interacting protein isoform X3

      Conserved Domains (6) summary
      TIGR00618
      Location:8591540
      sbcc; exonuclease SbcC
      COG1196
      Location:8591178
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:20972364
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:471572
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:18502204
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    7. XM_030246040.2XP_030101900.1  myosin phosphatase Rho-interacting protein isoform X17

      Conserved Domains (3) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:471572
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:7441054
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    8. XM_036156727.1XP_036012620.1  myosin phosphatase Rho-interacting protein isoform X4

      Conserved Domains (4) summary
      COG1196
      Location:8361155
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:692937
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17171
      Location:471549
      PH-like; Pleckstrin homology-like domain
    9. XM_006533432.3XP_006533495.1  myosin phosphatase Rho-interacting protein isoform X7

      Conserved Domains (6) summary
      TIGR00618
      Location:7771458
      sbcc; exonuclease SbcC
      COG1196
      Location:7771096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:20152282
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:389490
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:17682122
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    10. XM_036156733.1XP_036012626.1  myosin phosphatase Rho-interacting protein isoform X14

      Conserved Domains (3) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:389490
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:662998
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    11. XM_036156729.1XP_036012622.1  myosin phosphatase Rho-interacting protein isoform X8

      Conserved Domains (4) summary
      COG1196
      Location:7541073
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:610855
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17171
      Location:389467
      PH-like; Pleckstrin homology-like domain
    12. XM_036156734.1XP_036012627.1  myosin phosphatase Rho-interacting protein isoform X18

      Conserved Domains (3) summary
      COG1196
      Location:639952
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cl17171
      Location:389467
      PH-like; Pleckstrin homology-like domain
    13. XM_006533433.3XP_006533496.1  myosin phosphatase Rho-interacting protein isoform X9

      UniProtKB/TrEMBL
      Q5SWZ5
      Related
      ENSMUSP00000071081.9, ENSMUST00000066330.15
      Conserved Domains (6) summary
      TIGR00618
      Location:7411422
      sbcc; exonuclease SbcC
      COG1196
      Location:7411060
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:353454
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:19782206
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:17322086
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    14. XM_006533441.3XP_006533504.1  myosin phosphatase Rho-interacting protein isoform X20

      Conserved Domains (3) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:353454
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:626936
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    15. XM_006533440.3XP_006533503.1  myosin phosphatase Rho-interacting protein isoform X19

      UniProtKB/Swiss-Prot
      P97434
      Conserved Domains (3) summary
      cd01236
      Location:16151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:353454
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:626936
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    16. XM_030246041.1XP_030101901.1  myosin phosphatase Rho-interacting protein isoform X21

      Related
      ENSMUSP00000119422.2, ENSMUST00000132620.8
      Conserved Domains (2) summary
      cd13275
      Location:293394
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:566876
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    17. XM_011249055.2XP_011247357.2  myosin phosphatase Rho-interacting protein isoform X6

      Conserved Domains (3) summary
      COG1196
      Location:7991118
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:411512
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:655900
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    18. XM_036156731.1XP_036012624.1  myosin phosphatase Rho-interacting protein isoform X11

      Conserved Domains (3) summary
      COG1196
      Location:7891108
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:401502
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:645890
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    19. XM_036156728.1XP_036012621.1  myosin phosphatase Rho-interacting protein isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:8171136
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:429530
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:673918
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    20. XM_036156730.1XP_036012623.1  myosin phosphatase Rho-interacting protein isoform X10

      Conserved Domains (3) summary
      COG1196
      Location:6991018
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:311412
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:555800
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    21. XM_036156732.1XP_036012625.1  myosin phosphatase Rho-interacting protein isoform X12

      Conserved Domains (4) summary
      COG1196
      Location:479798
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:91192
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:14381729
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:335580
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RNA

    1. XR_003949455.2 RNA Sequence

    Support Center