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    Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 26921, updated on 2-Oct-2018

    Summary

    Official Symbol
    Map4k4provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 4provided by MGI
    Primary source
    MGI:MGI:1349394
    See related
    Ensembl:ENSMUSG00000026074 Vega:OTTMUSG00000050440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HGK; Nik; AU043147; AU045934; AW046177; 9430080K19Rik
    Expression
    Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues See more
    Orthologs

    Genomic context

    See Map4k4 in Genome Data Viewer
    Location:
    1; 1 B
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (39900912..40026310)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (39957758..40083155)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066B17 gene Neighboring gene predicted gene, 35600 Neighboring gene predicted gene, 16894 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    creatine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ARF protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 4
    Names
    HPK/GCK-like kinase HGK
    MAPK/ERK kinase kinase kinase 4
    MEK kinase kinase 4
    MEKKK 4
    NCK interacting kinase
    nck-interacting kinase
    NP_001239129.1
    NP_001239130.1
    NP_001239131.1
    NP_032722.2
    XP_006496104.1
    XP_006496105.1
    XP_006496106.1
    XP_006496107.1
    XP_006496108.1
    XP_006496109.1
    XP_011236832.1
    XP_017176483.1
    XP_017176487.1
    XP_017176490.1
    XP_017176491.1
    XP_017176493.1
    XP_017176499.1
    XP_017176500.1
    XP_017176502.1
    XP_017176505.1
    XP_017176507.1
    XP_017176510.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252200.1NP_001239129.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK159799, AV445090, BB651050, BC145390, BF721981, BQ571658, CJ142598, U88984
      Consensus CDS
      CCDS78573.1
      UniProtKB/Swiss-Prot
      P97820
      UniProtKB/TrEMBL
      A0A0A6YW53, B7ZNR8
      Related
      ENSMUSP00000141400.1, OTTMUSP00000068928, ENSMUST00000195860.5, OTTMUST00000127976
      Conserved Domains (3) summary
      smart00036
      Location:9701268
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001252201.1NP_001239130.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

      See identical proteins and their annotated locations for NP_001239130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the presence and absence of in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AK159799, AV445090, BB651050, BC141109, BC145390, BF721981, BQ571658, CJ142598, U88984
      Consensus CDS
      CCDS78576.1
      UniProtKB/Swiss-Prot
      P97820
      UniProtKB/TrEMBL
      B2RUE8, B7ZNR8
      Related
      ENSMUSP00000141862.1, OTTMUSP00000068927, ENSMUST00000193682.5, OTTMUST00000127975
      Conserved Domains (3) summary
      smart00036
      Location:9031201
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001252202.1NP_001239131.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

      See identical proteins and their annotated locations for NP_001239131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (4), compared to isoform 1.
      Source sequence(s)
      AK159799, AV445090, BB651050, BC145390, BC145391, BF721981, BQ571658, CJ142598, U88984
      Consensus CDS
      CCDS78575.1
      UniProtKB/Swiss-Prot
      P97820
      UniProtKB/TrEMBL
      B7ZNR8, B7ZNR9
      Related
      ENSMUSP00000142056.1, OTTMUSP00000068929, ENSMUST00000195259.5, OTTMUST00000127977
      Conserved Domains (3) summary
      smart00036
      Location:8901188
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    4. NM_008696.2NP_032722.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_032722.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC132909, AC166238, AK138966, CF531764, U88984
      Consensus CDS
      CCDS35546.1
      UniProtKB/Swiss-Prot
      P97820
      UniProtKB/TrEMBL
      A0A0A6YWR8, Q3UTY9
      Related
      ENSMUSP00000141665.1, OTTMUSP00000068931, ENSMUST00000192509.5, OTTMUST00000127981
      Conserved Domains (3) summary
      smart00036
      Location:9161214
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      39900912..40026310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496041.1XP_006496104.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

      Conserved Domains (3) summary
      smart00036
      Location:10651363
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011238530.1XP_011236832.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

      Conserved Domains (3) summary
      smart00036
      Location:10011299
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    3. XM_017321001.1XP_017176490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

    4. XM_017321010.1XP_017176499.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

    5. XM_017320994.1XP_017176483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

    6. XM_017320998.1XP_017176487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

    7. XM_017321011.1XP_017176500.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

    8. XM_006496044.1XP_006496107.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

      UniProtKB/TrEMBL
      F8VPL5
      Related
      ENSMUSP00000129796.2, OTTMUSP00000068932, ENSMUST00000168431.6, OTTMUST00000127982
      Conserved Domains (3) summary
      smart00036
      Location:9201218
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    9. XM_006496042.1XP_006496105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

      Conserved Domains (3) summary
      smart00036
      Location:10111309
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    10. XM_017321004.1XP_017176493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

    11. XM_017321018.1XP_017176507.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

    12. XM_017321021.1XP_017176510.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

    13. XM_017321002.1XP_017176491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

    14. XM_017321016.1XP_017176505.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

    15. XM_006496045.1XP_006496108.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

      Conserved Domains (3) summary
      smart00036
      Location:8931191
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    16. XM_006496043.1XP_006496106.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

      UniProtKB/TrEMBL
      A0A0A6YWM8
      Related
      ENSMUSP00000141613.1, OTTMUSP00000068930, ENSMUST00000195636.5, OTTMUST00000127978
      Conserved Domains (3) summary
      smart00036
      Location:9541252
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    17. XM_017321013.1XP_017176502.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

    18. XM_006496046.1XP_006496109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

      Conserved Domains (3) summary
      smart00036
      Location:8381136
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001784729.1 RNA Sequence

    2. XR_001784730.1 RNA Sequence

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