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    Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A [ Mus musculus (house mouse) ]

    Gene ID: 269181, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mgat4aprovided by MGI
    Official Full Name
    mannoside acetylglucosaminyltransferase 4, isoenzyme Aprovided by MGI
    Primary source
    MGI:MGI:2662992
    See related
    Ensembl:ENSMUSG00000026110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GnT-IVa; glcNAc-T-IVa; 9530018I07Rik
    Expression
    Broad expression in large intestine adult (RPKM 27.4), colon adult (RPKM 23.5) and 20 other tissues See more
    Orthologs

    Genomic context

    See Mgat4a in Genome Data Viewer
    Location:
    1; 1 B
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (37439340..37541047, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (37496185..37593104, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 homolog Neighboring gene G1 to S phase transition pseudogene Neighboring gene predicted gene, 39627 Neighboring gene RIKEN cDNA 2010300C02 gene Neighboring gene RIKEN cDNA 4930556I23 gene Neighboring gene RIKEN cDNA 4930470B04 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    protein N-linked glycosylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
    Names
    N-acetylglucosaminyltransferase IVa
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa
    UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa
    NP_001277730.1
    NP_776295.1
    XP_006496085.1
    XP_006496087.1
    XP_006496089.1
    XP_011236828.1
    XP_017176450.1
    XP_017176453.1
    XP_017176454.1
    XP_017176455.1
    XP_017176456.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290801.1NP_001277730.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2

      See identical proteins and their annotated locations for NP_001277730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC084390, AC140321, AK035332, AK076502, AK155724, AK163327
      Consensus CDS
      CCDS69882.1
      UniProtKB/Swiss-Prot
      Q812G0
      Related
      ENSMUSP00000121181.1, ENSMUST00000154819.7
      Conserved Domains (1) summary
      pfam04666
      Location:94371
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    2. NM_173870.3NP_776295.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1

      See identical proteins and their annotated locations for NP_776295.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC084390, AC140321, AK035332, AK076502, AK155724, AK163327
      Consensus CDS
      CCDS14893.1
      UniProtKB/Swiss-Prot
      Q812G0
      Related
      ENSMUSP00000114175.1, ENSMUST00000151952.7
      Conserved Domains (1) summary
      pfam04666
      Location:103380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      37439340..37541047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320966.1XP_017176455.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X5

      Conserved Domains (1) summary
      pfam04666
      Location:1135
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    2. XM_006496026.2XP_006496089.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X5

      See identical proteins and their annotated locations for XP_006496089.1

      Conserved Domains (1) summary
      pfam04666
      Location:1135
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    3. XM_017320965.1XP_017176454.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X5

      Conserved Domains (1) summary
      pfam04666
      Location:1135
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    4. XM_017320967.1XP_017176456.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X6

    5. XM_017320964.1XP_017176453.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X5

      Conserved Domains (1) summary
      pfam04666
      Location:1135
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    6. XM_011238526.2XP_011236828.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X3

      See identical proteins and their annotated locations for XP_011236828.1

      UniProtKB/Swiss-Prot
      Q812G0
      Conserved Domains (1) summary
      pfam04666
      Location:94371
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    7. XM_017320961.1XP_017176450.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

    8. XM_006496024.2XP_006496087.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2

      Conserved Domains (1) summary
      pfam04666
      Location:103380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    9. XM_006496022.3XP_006496085.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

      See identical proteins and their annotated locations for XP_006496085.1

      UniProtKB/Swiss-Prot
      Q812G0
      Conserved Domains (1) summary
      pfam04666
      Location:103380
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
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