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    Nup54 nucleoporin 54 [ Mus musculus (house mouse) ]

    Gene ID: 269113, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nup54provided by MGI
    Official Full Name
    nucleoporin 54provided by MGI
    Primary source
    MGI:MGI:1920460
    See related
    Ensembl:ENSMUSG00000034826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    54kD; 54kDa; 3110079L04Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.3), CNS E14 (RPKM 9.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nup54 in Genome Data Viewer
    Location:
    5; 5 E2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92563399..92583117, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92415540..92435259, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (92844566..92864225, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 3 Neighboring gene chemokine (C-X-C motif) ligand 11 Neighboring gene CWF19-like 1, cell cycle control pseudogene Neighboring gene predicted gene, 42114 Neighboring gene scavenger receptor class B, member 2 Neighboring gene microRNA 6415 Neighboring gene family with sequence similarity 47, member E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear pore complex protein Nup54
    Names
    54 kDa nucleoporin
    nucleoporin 54kDa
    nucleoporin Nup54

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359995.1NP_001346924.1  nuclear pore complex protein Nup54 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122365
      Conserved Domains (1) summary
      pfam13874
      Location:359494
      Nup54; Nucleoporin complex subunit 54
    2. NM_183392.2NP_899248.1  nuclear pore complex protein Nup54 isoform 2

      See identical proteins and their annotated locations for NP_899248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK133841, BQ032638, CJ049542
      Consensus CDS
      CCDS19430.1
      UniProtKB/Swiss-Prot
      Q8BTS4
      Related
      ENSMUSP00000046540.9, ENSMUST00000038514.15
      Conserved Domains (1) summary
      pfam13874
      Location:305440
      Nup54; Nucleoporin complex subunit 54

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92563399..92583117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534959.5XP_006535022.1  nuclear pore complex protein Nup54 isoform X2

      Conserved Domains (2) summary
      pfam13874
      Location:106243
      Nup54; Nucleoporin complex subunit 54
      pfam18437
      Location:259297
      Nup54_C; Nup54 C-terminal interacting domain
    2. XM_017320895.3XP_017176384.1  nuclear pore complex protein Nup54 isoform X2

      Conserved Domains (2) summary
      pfam13874
      Location:106243
      Nup54; Nucleoporin complex subunit 54
      pfam18437
      Location:259297
      Nup54_C; Nup54 C-terminal interacting domain
    3. XM_006534958.5XP_006535021.1  nuclear pore complex protein Nup54 isoform X1

      Conserved Domains (2) summary
      pfam13874
      Location:120257
      Nup54; Nucleoporin complex subunit 54
      pfam18437
      Location:273311
      Nup54_C; Nup54 C-terminal interacting domain
    4. XM_030254531.2XP_030110391.1  nuclear pore complex protein Nup54 isoform X1

      Conserved Domains (2) summary
      pfam13874
      Location:120257
      Nup54; Nucleoporin complex subunit 54
      pfam18437
      Location:273311
      Nup54_C; Nup54 C-terminal interacting domain

    RNA

    1. XR_004942520.1 RNA Sequence

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