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    Exo1 exonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 26909, updated on 5-Aug-2018

    Summary

    Official Symbol
    Exo1provided by MGI
    Official Full Name
    exonuclease 1provided by MGI
    Primary source
    MGI:MGI:1349427
    See related
    Ensembl:ENSMUSG00000039748 Vega:OTTMUSG00000050253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msa; 5730442G03Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 5.1), liver E14 (RPKM 3.6) and 11 other tissues See more
    Orthologs

    Genomic context

    See Exo1 in Genome Data Viewer
    Location:
    1 H4; 1 81.9 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (175880760..175911396)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (177810909..177841527)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene WD repeat domain 64 Neighboring gene predicted gene, 36360 Neighboring gene beclin 2 Neighboring gene phospholipase D family, member 5 Neighboring gene RNA binding motif protein 8A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    5'-3' exodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA 5'-3' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA 5'-3' exodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA 5'-3' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    single-stranded DNA 5'-3' exodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response mediated by circulating immunoglobulin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    isotype switching IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    nucleobase-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    somatic hypermutation of immunoglobulin genes IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    somatic hypermutation of immunoglobulin genes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exonuclease 1
    Names
    exonuclease I
    mExo1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012012.4NP_036142.2  exonuclease 1

      See identical proteins and their annotated locations for NP_036142.2

      Status: VALIDATED

      Source sequence(s)
      AC122854
      Consensus CDS
      CCDS15551.1
      UniProtKB/Swiss-Prot
      Q9QZ11
      Related
      ENSMUSP00000039376.6, OTTMUSP00000068832, ENSMUST00000039725.11, OTTMUST00000127652
      Conserved Domains (3) summary
      cd09908
      Location:213289
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1206
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      pfam10486
      Location:665779
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      175880760..175911396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496862.3XP_006496925.1  exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_006496925.1

      UniProtKB/Swiss-Prot
      Q9QZ11
      Conserved Domains (3) summary
      cd09908
      Location:213289
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1206
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      pfam10486
      Location:665779
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    2. XM_006496863.3XP_006496926.1  exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_006496926.1

      UniProtKB/Swiss-Prot
      Q9QZ11
      Conserved Domains (3) summary
      cd09908
      Location:213289
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1206
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      pfam10486
      Location:665779
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
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