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    Cops7b COP9 signalosome subunit 7B [ Mus musculus (house mouse) ]

    Gene ID: 26895, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cops7bprovided by MGI
    Official Full Name
    COP9 signalosome subunit 7Bprovided by MGI
    Primary source
    MGI:MGI:1349388
    See related
    Ensembl:ENSMUSG00000026240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Wsu66; D1Wsu66e; E130114M23
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 20.7), CNS E14 (RPKM 19.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cops7b in Genome Data Viewer
    Location:
    1 C5; 1 43.97 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86510363..86534550)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86582646..86606828)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (88483675..88503075)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30, pseudogene 6 Neighboring gene prothymosin alpha Neighboring gene phosphodiesterase 6D, cGMP-specific, rod, delta Neighboring gene predicted gene, 41908 Neighboring gene natriuretic peptide type C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 7b
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 7b
    COP9 complex S7b
    JAB1-containing signalosome subunit 7b
    SGN7b
    signalosome subunit 7b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360887.1NP_001347816.1  COP9 signalosome complex subunit 7b isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158132
      Consensus CDS
      CCDS15122.1
      Conserved Domains (1) summary
      smart00088
      Location:88177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    2. NM_001360888.1NP_001347817.1  COP9 signalosome complex subunit 7b isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC158132, AK053615
      Conserved Domains (2) summary
      smart00088
      Location:656
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:4594
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    3. NM_172974.3NP_766562.1  COP9 signalosome complex subunit 7b isoform a

      See identical proteins and their annotated locations for NP_766562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158132, AI121193, AK081309, CN721267
      Consensus CDS
      CCDS15122.1
      UniProtKB/Swiss-Prot
      Q8BV13
      Related
      ENSMUSP00000113587.2, ENSMUST00000121534.8
      Conserved Domains (1) summary
      smart00088
      Location:88177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86510363..86534550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254496.2XP_030110356.1  COP9 signalosome complex subunit 7b isoform X2

      Conserved Domains (2) summary
      smart00088
      Location:656
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:4594
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    2. XM_006529625.5XP_006529688.1  COP9 signalosome complex subunit 7b isoform X1

      Conserved Domains (2) summary
      smart00753
      Location:76165
      PAM; PCI/PINT associated module
      pfam18392
      Location:154203
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    3. XM_036165290.1XP_036021183.1  COP9 signalosome complex subunit 7b isoform X2

      Conserved Domains (2) summary
      smart00088
      Location:656
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:4594
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
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