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    Cops7a COP9 signalosome subunit 7A [ Mus musculus (house mouse) ]

    Gene ID: 26894, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cops7aprovided by MGI
    Official Full Name
    COP9 signalosome subunit 7Aprovided by MGI
    Primary source
    MGI:MGI:1349400
    See related
    Ensembl:ENSMUSG00000030127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGN7a; D6Ertd35e
    Expression
    Ubiquitous expression in testis adult (RPKM 98.1), adrenal adult (RPKM 67.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cops7a in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (124958411..124965529, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124908429..124915547, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene predicted gene, 38896 Neighboring gene myeloid leukemia factor 2 Neighboring gene predicted gene, 40398 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 7a
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 7a
    COP9 (constitutive photomorphogenic), subunit 7a
    COP9 complex S7a
    JAB1-containing signalosome subunit 7a
    signalosome subunit 7a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164089.2NP_001157561.1  COP9 signalosome complex subunit 7a isoform 2

      See identical proteins and their annotated locations for NP_001157561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate 5' UTR, and has a distinct 3' terminal exon and UTR, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC164563
      Consensus CDS
      CCDS51909.1
      UniProtKB/Swiss-Prot
      Q9CZ04
      Related
      ENSMUSP00000108058.2, ENSMUST00000112439.8
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    2. NM_001355541.1NP_001342470.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC164563
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    3. NM_001355542.1NP_001342471.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC164563
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    4. NM_012003.3NP_036133.1  COP9 signalosome complex subunit 7a isoform 1

      See identical proteins and their annotated locations for NP_036133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC164563
      Consensus CDS
      CCDS20539.1
      UniProtKB/Swiss-Prot
      Q9CZ04
      Related
      ENSMUSP00000032220.8, ENSMUST00000032220.14
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      124958411..124965529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506161.2XP_006506224.1  COP9 signalosome complex subunit 7a isoform X1

      See identical proteins and their annotated locations for XP_006506224.1

      UniProtKB/Swiss-Prot
      Q9CZ04
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    2. XM_006506160.2XP_006506223.1  COP9 signalosome complex subunit 7a isoform X1

      See identical proteins and their annotated locations for XP_006506223.1

      UniProtKB/Swiss-Prot
      Q9CZ04
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    3. XM_006506159.3XP_006506222.1  COP9 signalosome complex subunit 7a isoform X1

      See identical proteins and their annotated locations for XP_006506222.1

      UniProtKB/Swiss-Prot
      Q9CZ04
      Related
      ENSMUSP00000117584.1, ENSMUST00000129976.7
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    4. XM_006506157.1XP_006506220.1  COP9 signalosome complex subunit 7a isoform X4

      Conserved Domains (1) summary
      smart00753
      Location:103193
      PAM; PCI/PINT associated module
    5. XM_011241366.1XP_011239668.1  COP9 signalosome complex subunit 7a isoform X3

      Conserved Domains (1) summary
      smart00753
      Location:106196
      PAM; PCI/PINT associated module
    6. XM_006506162.3XP_006506225.1  COP9 signalosome complex subunit 7a isoform X2

      UniProtKB/Swiss-Prot
      Q9CZ04
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    7. XM_011241365.2XP_011239667.1  COP9 signalosome complex subunit 7a isoform X2

      See identical proteins and their annotated locations for XP_011239667.1

      UniProtKB/Swiss-Prot
      Q9CZ04
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    8. XM_017321593.1XP_017177082.1  COP9 signalosome complex subunit 7a isoform X2

      UniProtKB/Swiss-Prot
      Q9CZ04
      Conserved Domains (1) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
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