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    Brpf3 bromodomain and PHD finger containing, 3 [ Mus musculus (house mouse) ]

    Gene ID: 268936, updated on 25-Nov-2021

    Summary

    Official Symbol
    Brpf3provided by MGI
    Official Full Name
    bromodomain and PHD finger containing, 3provided by MGI
    Primary source
    MGI:MGI:2146836
    See related
    Ensembl:ENSMUSG00000063952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI413466; AW493400; mKIAA1286
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 22.7), liver E14 (RPKM 19.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Brpf3 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29020088..29057763)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28801126..28838789)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (28938071..28975734)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 14 Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 pseudogene Neighboring gene mitogen-activated protein kinase 13 Neighboring gene predicted gene, 35883 Neighboring gene patatin-like phospholipase domain containing 1 Neighboring gene RIKEN cDNA 1700030A11 gene Neighboring gene BCL2 interacting protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1286, MGC58603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bromodomain and PHD finger-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081315.1NP_001074784.1  bromodomain and PHD finger-containing protein 3

      See identical proteins and their annotated locations for NP_001074784.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140278
      Consensus CDS
      CCDS37532.1
      UniProtKB/TrEMBL
      B2KF05
      Related
      ENSMUSP00000004985.10, ENSMUST00000004985.11
      Conserved Domains (4) summary
      cd05839
      Location:10731188
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29020088..29057763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524328.5XP_006524391.1  bromodomain and PHD finger-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006524391.1

      Related
      ENSMUSP00000156455.2, ENSMUST00000233701.2
      Conserved Domains (4) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      PHA03307
      Location:8281095
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    2. XM_036160628.1XP_036016521.1  bromodomain and PHD finger-containing protein 3 isoform X3

      Conserved Domains (4) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      PHA03307
      Location:8311037
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    3. XM_006524330.5XP_006524393.1  bromodomain and PHD finger-containing protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006524393.1

      Conserved Domains (3) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    4. XM_006524331.4XP_006524394.1  bromodomain and PHD finger-containing protein 3 isoform X5

      See identical proteins and their annotated locations for XP_006524394.1

      Conserved Domains (3) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    5. XM_006524334.4XP_006524397.1  bromodomain and PHD finger-containing protein 3 isoform X7

      See identical proteins and their annotated locations for XP_006524397.1

      Related
      ENSMUSP00000156836.2, ENSMUST00000232705.2
      Conserved Domains (2) summary
      COG5141
      Location:117622
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cl22851
      Location:269386
      PHD_SF; PHD finger superfamily
    6. XM_006524326.5XP_006524389.1  bromodomain and PHD finger-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006524389.1

      UniProtKB/TrEMBL
      B2KF05
      Conserved Domains (4) summary
      cd05839
      Location:10731188
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    7. XM_030249830.2XP_030105690.1  bromodomain and PHD finger-containing protein 3 isoform X1

      Conserved Domains (4) summary
      cd05839
      Location:10731188
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:117603
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    8. XM_006524332.5XP_006524395.1  bromodomain and PHD finger-containing protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006524395.1

      Related
      ENSMUSP00000156780.2, ENSMUST00000156029.8
      Conserved Domains (2) summary
      cd05839
      Location:575690
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:94191
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

    RNA

    1. XR_003952129.2 RNA Sequence

    2. XR_004939534.1 RNA Sequence

    3. XR_385332.5 RNA Sequence

    4. XR_004939535.1 RNA Sequence

    5. XR_003952130.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199061.1: Suppressed sequence

      Description
      NM_199061.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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