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    Brpf3 bromodomain and PHD finger containing, 3 [ Mus musculus (house mouse) ]

    Gene ID: 268936, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brpf3provided by MGI
    Official Full Name
    bromodomain and PHD finger containing, 3provided by MGI
    Primary source
    MGI:MGI:2146836
    See related
    Ensembl:ENSMUSG00000063952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI413466; AW493400; mKIAA1286
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 22.7), liver E14 (RPKM 19.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brpf3 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (28800763..28838789)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (28938071..28975734)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 14 Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 pseudogene Neighboring gene mitogen-activated protein kinase 13 Neighboring gene uncharacterized LOC105246245 Neighboring gene patatin-like phospholipase domain containing 1 Neighboring gene RIKEN cDNA 4930539E08 gene Neighboring gene RIKEN cDNA 1700030A11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1286, MGC58603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bromodomain and PHD finger-containing protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081315.1NP_001074784.1  bromodomain and PHD finger-containing protein 3

      See identical proteins and their annotated locations for NP_001074784.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140278
      Consensus CDS
      CCDS37532.1
      UniProtKB/TrEMBL
      B2KF05
      Related
      ENSMUSP00000004985.9, ENSMUST00000004985.10
      Conserved Domains (5) summary
      cd05839
      Location:10731188
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      28800763..28838789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524328.3XP_006524391.1  bromodomain and PHD finger-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006524391.1

      Related
      ENSMUSP00000156455.1, ENSMUST00000233701.1
      Conserved Domains (4) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
    2. XM_017317484.1XP_017172973.1  bromodomain and PHD finger-containing protein 3 isoform X2

    3. XM_006524329.3XP_006524392.1  bromodomain and PHD finger-containing protein 3 isoform X4

      Conserved Domains (4) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
    4. XM_006524330.3XP_006524393.1  bromodomain and PHD finger-containing protein 3 isoform X5

      See identical proteins and their annotated locations for XP_006524393.1

      Conserved Domains (4) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
    5. XM_006524331.3XP_006524394.1  bromodomain and PHD finger-containing protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006524394.1

      Conserved Domains (4) summary
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
    6. XM_006524333.3XP_006524396.1  bromodomain and PHD finger-containing protein 3 isoform X8

      Conserved Domains (4) summary
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
      cl02556
      Location:592621
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl22851
      Location:269386
      PHD_SF; PHD finger superfamily
    7. XM_006524334.3XP_006524397.1  bromodomain and PHD finger-containing protein 3 isoform X9

      See identical proteins and their annotated locations for XP_006524397.1

      Conserved Domains (4) summary
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
      cl02556
      Location:592622
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl22851
      Location:269386
      PHD_SF; PHD finger superfamily
    8. XM_017317485.1XP_017172974.1  bromodomain and PHD finger-containing protein 3 isoform X10

      Related
      ENSMUSP00000156836.1, ENSMUST00000232705.1
    9. XM_006524326.3XP_006524389.1  bromodomain and PHD finger-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006524389.1

      UniProtKB/TrEMBL
      B2KF05
      Conserved Domains (5) summary
      cd05839
      Location:10731188
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
    10. XM_017317483.1XP_017172972.1  bromodomain and PHD finger-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      B2KF05
      Conserved Domains (5) summary
      cd05839
      Location:10731188
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:592689
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48194
      EPL1; Enhancer of polycomb-like
    11. XM_006524332.3XP_006524395.1  bromodomain and PHD finger-containing protein 3 isoform X7

      See identical proteins and their annotated locations for XP_006524395.1

      Related
      ENSMUSP00000156780.1, ENSMUST00000156029.7
      Conserved Domains (2) summary
      cd05839
      Location:575690
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:94191
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

    RNA

    1. XR_385332.3 RNA Sequence

    2. XR_385333.3 RNA Sequence

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187005.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1491373..1529180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199061.1: Suppressed sequence

      Description
      NM_199061.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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