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    Casp8ap2 caspase 8 associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 26885, updated on 27-Nov-2024

    Summary

    Official Symbol
    Casp8ap2provided by MGI
    Official Full Name
    caspase 8 associated protein 2provided by MGI
    Primary source
    MGI:MGI:1349399
    See related
    Ensembl:ENSMUSG00000028282 AllianceGenome:MGI:1349399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLASH; D4Ertd659e
    Summary
    Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Predicted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.6), placenta adult (RPKM 3.7) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Casp8ap2 in Genome Data Viewer
    Location:
    4 A5; 4 14.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32615462..32653271)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32615470..32653271)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene BTB and CNC homology, basic leucine zipper transcription factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32647355-32647538 Neighboring gene STARR-seq mESC enhancer starr_09865 Neighboring gene STARR-positive B cell enhancer ABC_E6158 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene gap junction protein, alpha 10 Neighboring gene midasin AAA ATPase 1 Neighboring gene predicted gene, 42267

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • mKIAA1315

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO polymer binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO polymer binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    CASP8-associated protein 2
    Names
    FLICE-associated huge protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122978.2NP_001116450.1  CASP8-associated protein 2

      See identical proteins and their annotated locations for NP_001116450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK142148, AL805973, CA526466
      Consensus CDS
      CCDS18016.1
      UniProtKB/Swiss-Prot
      B1AX74, Q9CSW2, Q9WUF3
      Related
      ENSMUSP00000136016.2, ENSMUST00000178925.8
      Conserved Domains (3) summary
      cd12202
      Location:18961960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10361156
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:75142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_011997.3NP_036127.2  CASP8-associated protein 2

      See identical proteins and their annotated locations for NP_036127.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL805973, AL954737
      Consensus CDS
      CCDS18016.1
      UniProtKB/Swiss-Prot
      B1AX74, Q9CSW2, Q9WUF3
      Related
      ENSMUSP00000029950.4, ENSMUST00000029950.10
      Conserved Domains (3) summary
      cd12202
      Location:18961960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10361156
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:75142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32615462..32653271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537949.2XP_006538012.1  CASP8-associated protein 2 isoform X1

      Conserved Domains (3) summary
      cd12202
      Location:19402004
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10801200
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:119186
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006537950.3XP_006538013.1  CASP8-associated protein 2 isoform X2

      Conserved Domains (3) summary
      cd12202
      Location:19382002
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10781198
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:126184
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)