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    Casp8ap2 caspase 8 associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 26885, updated on 31-Jan-2019

    Summary

    Official Symbol
    Casp8ap2provided by MGI
    Official Full Name
    caspase 8 associated protein 2provided by MGI
    Primary source
    MGI:MGI:1349399
    See related
    Ensembl:ENSMUSG00000028282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLASH; D4Ertd659e
    Expression
    Broad expression in CNS E11.5 (RPKM 6.6), placenta adult (RPKM 3.7) and 17 other tissues See more
    Orthologs

    Genomic context

    See Casp8ap2 in Genome Data Viewer
    Location:
    4 A5; 4 14.27 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (32615470..32653271)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (32702448..32740240)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene BTB and CNC homology, basic leucine zipper transcription factor 2 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene gap junction protein, alpha 10 Neighboring gene midasin AAA ATPase 1 Neighboring gene predicted gene, 42267

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1315

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SUMO polymer binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Fas signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CASP8-associated protein 2
    Names
    FLICE-associated huge protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122978.2NP_001116450.1  CASP8-associated protein 2

      See identical proteins and their annotated locations for NP_001116450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK142148, AL805973, CA526466
      Consensus CDS
      CCDS18016.1
      UniProtKB/Swiss-Prot
      Q9WUF3
      UniProtKB/TrEMBL
      Q3UQU1
      Related
      ENSMUSP00000136016.1, ENSMUST00000178925.7
      Conserved Domains (3) summary
      cd12202
      Location:18961960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10361156
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:75142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_011997.3NP_036127.2  CASP8-associated protein 2

      See identical proteins and their annotated locations for NP_036127.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL805973, AL954737
      Consensus CDS
      CCDS18016.1
      UniProtKB/Swiss-Prot
      Q9WUF3
      Related
      ENSMUSP00000029950.3, ENSMUST00000029950.9
      Conserved Domains (3) summary
      cd12202
      Location:18961960
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10361156
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:75142
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      32615470..32653271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537949.1XP_006538012.1  CASP8-associated protein 2 isoform X1

      Conserved Domains (3) summary
      cd12202
      Location:19402004
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10801200
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:119186
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006537950.1XP_006538013.1  CASP8-associated protein 2 isoform X2

      Conserved Domains (3) summary
      cd12202
      Location:19382002
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      TIGR04313
      Location:10781198
      aro_clust_Mycop; aromatic cluster surface protein
      cl23720
      Location:126184
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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