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    Rnf31 ring finger protein 31 [ Mus musculus (house mouse) ]

    Gene ID: 268749, updated on 31-Jan-2019

    Summary

    Official Symbol
    Rnf31provided by MGI
    Official Full Name
    ring finger protein 31provided by MGI
    Primary source
    MGI:MGI:1934704
    See related
    Ensembl:ENSMUSG00000047098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HOIP; Paul; AL033293; BC031509; Flj10111; mFLJ00217
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.8), spleen adult (RPKM 23.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rnf31 in Genome Data Viewer
    Location:
    14; 14 C3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (55591713..55603674)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56210627..56222508)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9 Neighboring gene proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    CD40 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein linear polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CD40 receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    LUBAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF31
    Names
    HOIL-1-interacting protein
    RING-type E3 ubiquitin transferase RNF31
    putative Ariadne-like ubiquitin ligase
    NP_919327.2
    XP_006519125.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194346.3NP_919327.2  E3 ubiquitin-protein ligase RNF31

      See identical proteins and their annotated locations for NP_919327.2

      Status: VALIDATED

      Source sequence(s)
      AC174678, BC057595, BY426496
      Consensus CDS
      CCDS27118.1
      UniProtKB/Swiss-Prot
      Q924T7
      Related
      ENSMUSP00000019443.8, ENSMUST00000019443.14
      Conserved Domains (6) summary
      smart00647
      Location:773835
      IBR; In Between Ring fingers
      cd14325
      Location:565619
      UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
      sd00029
      Location:348367
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam04981
      Location:693743
      NMD3; NMD3 family
      pfam16678
      Location:477621
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
      cl15262
      Location:51152
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      55591713..55603674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519062.2XP_006519125.1  E3 ubiquitin-protein ligase RNF31 isoform X1

      Conserved Domains (6) summary
      smart00647
      Location:776838
      IBR; In Between Ring fingers
      cd14325
      Location:568622
      UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
      sd00029
      Location:351370
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam04981
      Location:696746
      NMD3; NMD3 family
      pfam16678
      Location:480624
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
      cl15262
      Location:51152
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

    RNA

    1. XR_383184.1 RNA Sequence

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