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    Tox4 TOX high mobility group box family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 268741, updated on 7-Sep-2023


    Official Symbol
    Tox4provided by MGI
    Official Full Name
    TOX high mobility group box family member 4provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000016831 AllianceGenome:MGI:1915389
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LCP1; A630040M18; 5730589K01Rik
    Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in thymus adult (RPKM 22.1), ovary adult (RPKM 18.1) and 28 other tissues See more
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    Genomic context

    See Tox4 in Genome Data Viewer
    14 C2; 14 26.88 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_04 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52516603..52532966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52279146..52295509)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene predicted gene, 26590 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52864139-52864322 Neighboring gene STARR-seq mESC enhancer starr_36702 Neighboring gene RAB2B, member RAS oncogene family Neighboring gene predicted gene, 23758 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52924722-52924905 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Neighboring gene spalt like transcription factor 2 Neighboring gene predicted gene, 53857 Neighboring gene predicted gene, 26328

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    TOX high mobility group box family member 4
    epidermal Langerhans cell protein LCP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023434.3NP_075923.2  TOX high mobility group box family member 4

      See identical proteins and their annotated locations for NP_075923.2

      Status: VALIDATED

      Source sequence(s)
      AK137050, AK147023, AK173012, BY327085
      Consensus CDS
      Q3UGN7, Q80UI2, Q8BU11, Q99PN9, Q9CS16
      Q3U661, Q3UVQ1, Q6A006
      ENSMUSP00000022766.7, ENSMUST00000022766.8
      Conserved Domains (3) summary
      PHA03160; hypothetical protein; Provisional
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000080.7 Reference GRCm39 C57BL/6J

      GenBank, FASTA, Sequence Viewer (Graphics)