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    Ccnb1 cyclin B1 [ Mus musculus (house mouse) ]

    Gene ID: 268697, updated on 26-Feb-2019

    Summary

    Official Symbol
    Ccnb1provided by MGI
    Official Full Name
    cyclin B1provided by MGI
    Primary source
    MGI:MGI:88302
    See related
    Ensembl:ENSMUSG00000041431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycB1; Cycb-4; Cycb-5; Ccnb1-rs1; Cycb1-rs1; Ccnb1-rs13
    Expression
    Biased expression in liver E14 (RPKM 79.4), liver E14.5 (RPKM 71.8) and 11 other tissues See more
    Orthologs

    Genomic context

    See Ccnb1 in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (100778739..100786486, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (101548694..101556441, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene centromere protein H Neighboring gene solute carrier family 30 (zinc transporter), member 5 Neighboring gene predicted gene, 41040

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC18763, MGC90915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclin-dependent protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    patched binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-S10 phosphorylation involved in chromosome condensation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic metaphase plate congression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin B1-CDK1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin B1-CDK1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G2/mitotic-specific cyclin-B1
    Names
    cyclin B1, related sequence 1
    cyclin B1, related sequence 13

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172301.3NP_758505.2  G2/mitotic-specific cyclin-B1

      See identical proteins and their annotated locations for NP_758505.2

      Status: PROVISIONAL

      Source sequence(s)
      AC112701
      Consensus CDS
      CCDS36768.1
      UniProtKB/Swiss-Prot
      P24860
      UniProtKB/TrEMBL
      Q3TQW9
      Related
      ENSMUSP00000071989.8, ENSMUST00000072119.14
      Conserved Domains (2) summary
      pfam00134
      Location:170295
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:297415
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      100778739..100786486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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