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    Ccnb1 cyclin B1 [ Mus musculus (house mouse) ]

    Gene ID: 268697, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ccnb1provided by MGI
    Official Full Name
    cyclin B1provided by MGI
    Primary source
    MGI:MGI:88302
    See related
    Ensembl:ENSMUSG00000041431 AllianceGenome:MGI:88302
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycB1; Cycb-4; Cycb-5; Ccnb1-rs1; Cycb1-rs1; Ccnb1-rs13
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and patched binding activity. Acts upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and protein phosphorylation. Located in cytoplasm; membrane; and nucleus. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 79.4), liver E14.5 (RPKM 71.8) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Ccnb1 in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100915247..100922994, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100778739..100786486, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene centromere protein H Neighboring gene STARR-positive B cell enhancer ABC_E1886 Neighboring gene STARR-seq mESC enhancer starr_35481 Neighboring gene solute carrier family 30 (zinc transporter), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E4088 Neighboring gene predicted gene, 41040

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC18763, MGC90915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables patched binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables patched binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic metaphase chromosome alignment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of cyclin B1-CDK1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin B1-CDK1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cyclin B1-CDK1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of outer kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G2/mitotic-specific cyclin-B1
    Names
    cyclin B1, related sequence 1
    cyclin B1, related sequence 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172301.3NP_758505.2  G2/mitotic-specific cyclin-B1

      See identical proteins and their annotated locations for NP_758505.2

      Status: PROVISIONAL

      Source sequence(s)
      AC112701
      Consensus CDS
      CCDS36768.1
      UniProtKB/Swiss-Prot
      P24860
      UniProtKB/TrEMBL
      Q3TFV6, Q3TQW9, Q3UWL3
      Related
      ENSMUSP00000071989.9, ENSMUST00000072119.15
      Conserved Domains (2) summary
      pfam00134
      Location:170295
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:297415
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100915247..100922994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)