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    Ube2z ubiquitin-conjugating enzyme E2Z [ Mus musculus (house mouse) ]

    Gene ID: 268470, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ube2zprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Zprovided by MGI
    Primary source
    MGI:MGI:1343160
    See related
    Ensembl:ENSMUSG00000014349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW049199; D11Moh35; C030047H17Rik
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 37.8), placenta adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2z in Genome Data Viewer
    Location:
    11 D; 11 59.28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95938257..95956190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96047431..96065364, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (95908745..95926678, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24949 Neighboring gene SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) Neighboring gene predicted gene, 22423

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 Z
    Names
    E2 ubiquitin-conjugating enzyme Z
    uba6-specific E2 conjugating enzyme 1
    ubiquitin carrier protein Z
    ubiquitin-conjugating enzyme E2Z (putative)
    ubiquitin-protein ligase Z
    use1
    NP_758504.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172300.3NP_758504.3  ubiquitin-conjugating enzyme E2 Z

      See identical proteins and their annotated locations for NP_758504.3

      Status: VALIDATED

      Source sequence(s)
      AK153328, AL603682, CA317477
      Consensus CDS
      CCDS36289.1
      UniProtKB/Swiss-Prot
      Q3UE37
      Related
      ENSMUSP00000098097.5, ENSMUST00000100528.5
      Conserved Domains (1) summary
      cd00195
      Location:105223
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95938257..95956190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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