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    Eme1 essential meiotic structure-specific endonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 268465, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eme1provided by MGI
    Official Full Name
    essential meiotic structure-specific endonuclease 1provided by MGI
    Primary source
    MGI:MGI:3576783
    See related
    Ensembl:ENSMUSG00000039055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6820428D13
    Expression
    Broad expression in CNS E11.5 (RPKM 17.9), cortex adult (RPKM 15.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Eme1 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (94644998..94653785, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (94506316..94515068, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene chondroadherin Neighboring gene leucine rich repeat containing 59 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene xylosyltransferase II Neighboring gene predicted gene 11541

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC106543

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to crossover junction endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-S DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    crossover junction endonuclease EME1
    Names
    essential meiotic endonuclease 1 homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177752.5NP_808420.1  crossover junction endonuclease EME1

      See identical proteins and their annotated locations for NP_808420.1

      Status: VALIDATED

      Source sequence(s)
      AL645764
      Consensus CDS
      CCDS25262.1
      UniProtKB/Swiss-Prot
      Q8BJW7
      Related
      ENSMUSP00000036361.4, ENSMUST00000039949.4
      Conserved Domains (2) summary
      pfam02732
      Location:271439
      ERCC4; ERCC4 domain
      pfam07304
      Location:56115
      SRA1; Steroid receptor RNA activator (SRA1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      94644998..94653785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249045.1XP_011247347.1  crossover junction endonuclease EME1 isoform X2

      Conserved Domains (1) summary
      pfam02732
      Location:148197
      ERCC4; ERCC4 domain
    2. XM_006533408.2XP_006533471.1  crossover junction endonuclease EME1 isoform X1

      Conserved Domains (2) summary
      pfam02732
      Location:409458
      ERCC4; ERCC4 domain
      pfam07304
      Location:56115
      SRA1; Steroid receptor RNA activator (SRA1)
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