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    Eme1 essential meiotic structure-specific endonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 268465, updated on 23-Jun-2021

    Summary

    Official Symbol
    Eme1provided by MGI
    Official Full Name
    essential meiotic structure-specific endonuclease 1provided by MGI
    Primary source
    MGI:MGI:3576783
    See related
    Ensembl:ENSMUSG00000039055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6820428D13
    Expression
    Broad expression in CNS E11.5 (RPKM 17.9), cortex adult (RPKM 15.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eme1 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94535798..94544611, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94644972..94653836, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (94506316..94515068, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene chondroadherin Neighboring gene leucine rich repeat containing 59 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene xylosyltransferase II Neighboring gene predicted gene 11541

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC106543

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    crossover junction endonuclease EME1
    Names
    essential meiotic endonuclease 1 homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379688.1NP_001366617.1  crossover junction endonuclease EME1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645764
      Conserved Domains (1) summary
      cd20081
      Location:243471
      XPF_nuclease_EME1; XPF-like nuclease domain of crossover junction endonuclease EME1
    2. NM_177752.5NP_808420.1  crossover junction endonuclease EME1 isoform 2

      See identical proteins and their annotated locations for NP_808420.1

      Status: VALIDATED

      Source sequence(s)
      AL645764
      Consensus CDS
      CCDS25262.1
      UniProtKB/Swiss-Prot
      Q8BJW7
      Related
      ENSMUSP00000036361.5, ENSMUST00000039949.5
      Conserved Domains (2) summary
      pfam02732
      Location:271439
      ERCC4; ERCC4 domain
      pfam07304
      Location:56115
      SRA1; Steroid receptor RNA activator (SRA1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94535798..94544611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246037.2XP_030101897.1  crossover junction endonuclease EME1 isoform X2

    2. XM_011249045.1XP_011247347.1  crossover junction endonuclease EME1 isoform X1

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