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    Phf12 PHD finger protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 268448, updated on 23-Jun-2021

    Summary

    Official Symbol
    Phf12provided by MGI
    Official Full Name
    PHD finger protein 12provided by MGI
    Primary source
    MGI:MGI:1924057
    See related
    Ensembl:ENSMUSG00000037791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PF; PF1; mKIAA1523; F630045O13; 2410142K10Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.0), spleen adult (RPKM 20.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Phf12 in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77873515..77921365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77982733..78030539)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77796318..77844038)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11190 Neighboring gene seizure related gene 6 Neighboring gene predicted gene, 53689 Neighboring gene predicted gene, 51908 Neighboring gene dehydrogenase/reductase (SDR family) member 13, opposite strand Neighboring gene dehydrogenase/reductase (SDR family) member 13 Neighboring gene flotillin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Sin3 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    PHD finger protein 12
    Names
    PHD factor 1
    PHD zinc finger transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174852.3NP_777277.2  PHD finger protein 12

      See identical proteins and their annotated locations for NP_777277.2

      Status: VALIDATED

      Source sequence(s)
      AK053787, BC043080
      Consensus CDS
      CCDS48855.1
      UniProtKB/Swiss-Prot
      Q5SPL2
      UniProtKB/TrEMBL
      Q3U2C9
      Related
      ENSMUSP00000044990.8, ENSMUST00000049167.14
      Conserved Domains (4) summary
      cd00060
      Location:812867
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15533
      Location:58102
      PHD1_PHF12; PHD finger 1 found in PHD finger protein 12 (PHF12)
      cd15534
      Location:273318
      PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
      pfam16737
      Location:203241
      PHF12_MRG_bd; PHD finger protein 12 MRG binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77873515..77921365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533400.3XP_006533463.1  PHD finger protein 12 isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:507721
      PHA03247; large tegument protein UL36; Provisional
      cd00060
      Location:764819
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15533
      Location:58102
      PHD1_PHF12; PHD finger 1 found in PHD finger protein 12 (PHF12)
      cd15534
      Location:273318
      PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
      pfam16737
      Location:203241
      PHF12_MRG_bd; PHD finger protein 12 MRG binding domain
    2. XM_030246034.1XP_030101894.1  PHD finger protein 12 isoform X3

      Conserved Domains (4) summary
      PHA03247
      Location:290504
      PHA03247; large tegument protein UL36; Provisional
      cd00060
      Location:595650
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15534
      Location:56101
      PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
      pfam16737
      Location:124
      PHF12_MRG_bd; PHD finger protein 12 MRG binding domain
    3. XM_036156716.1XP_036012609.1  PHD finger protein 12 isoform X2

      Conserved Domains (4) summary
      PHA03247
      Location:417631
      PHA03247; large tegument protein UL36; Provisional
      cd00060
      Location:722777
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15534
      Location:183228
      PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
      pfam16737
      Location:113151
      PHF12_MRG_bd; PHD finger protein 12 MRG binding domain
    4. XM_017314564.3XP_017170053.1  PHD finger protein 12 isoform X2

      Conserved Domains (4) summary
      PHA03247
      Location:417631
      PHA03247; large tegument protein UL36; Provisional
      cd00060
      Location:722777
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15534
      Location:183228
      PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
      pfam16737
      Location:113151
      PHF12_MRG_bd; PHD finger protein 12 MRG binding domain

    RNA

    1. XR_388469.3 RNA Sequence

    2. XR_003949453.2 RNA Sequence

    3. XR_004936972.1 RNA Sequence

    4. XR_004936973.1 RNA Sequence

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