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    Alkbh5 alkB homolog 5, RNA demethylase [ Mus musculus (house mouse) ]

    Gene ID: 268420, updated on 22-Aug-2021

    Summary

    Official Symbol
    Alkbh5provided by MGI
    Official Full Name
    alkB homolog 5, RNA demethylaseprovided by MGI
    Primary source
    MGI:MGI:2144489
    See related
    Ensembl:ENSMUSG00000042650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abh; Ofo; Abh5; Ofoxd; AW050020; AW215868; E130207K11
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.2), ovary adult (RPKM 17.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Alkbh5 in Genome Data Viewer
    Location:
    11; 11 B2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60428509..60449338)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60537683..60558512)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60351185..60372014)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene myosin XV Neighboring gene predicted gene, 51901 Neighboring gene predicted gene, 53694 Neighboring gene ubiquitin-60S ribosomal protein L40 pseudogene Neighboring gene ubiquitin-60S ribosomal protein L40 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA N6-methyladenosine dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables mRNA N6-methyladenosine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidative RNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxidative single-stranded RNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in oxidative single-stranded RNA demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oxidative single-stranded RNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA demethylase ALKBH5
    Names
    alkB, alkylation repair homolog 5
    alkylated DNA repair protein alkB homolog 5
    alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
    oxoglutarate and iron-dependent oxygenase domain containing
    probable alpha-ketoglutarate-dependent dioxygenase ABH5
    NP_766531.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172943.4NP_766531.2  RNA demethylase ALKBH5

      See identical proteins and their annotated locations for NP_766531.2

      Status: VALIDATED

      Source sequence(s)
      AL596386
      Consensus CDS
      CCDS24794.1
      UniProtKB/Swiss-Prot
      Q3TSG4
      Related
      ENSMUSP00000049116.4, ENSMUST00000044250.4
      Conserved Domains (1) summary
      cl21496
      Location:137271
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60428509..60449338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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