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    Ahsa2 AHA1, activator of heat shock protein ATPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 268390, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ahsa2provided by MGI
    Official Full Name
    AHA1, activator of heat shock protein ATPase 2provided by MGI
    Primary source
    MGI:MGI:1916133
    See related
    Ensembl:ENSMUSG00000020288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in CNS E18 (RPKM 24.7), CNS E14 (RPKM 23.2) and 26 other tissues See more
    Orthologs

    Genomic context

    See Ahsa2 in Genome Data Viewer
    Location:
    11; 11 A3.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (23487882..23498039, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (23387882..23397946, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene exportin 1 Neighboring gene predicted gene 3718 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene selenoprotein K, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ36626, 1110064P04Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    activator of 90 kDa heat shock protein ATPase homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290654.1NP_001277583.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001277583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream AUG, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK034661, AK137116, CJ147821
      Consensus CDS
      CCDS70149.1
      UniProtKB/Swiss-Prot
      Q8N9S3
      Related
      ENSMUSP00000105166.1, ENSMUST00000109539.7
      Conserved Domains (2) summary
      cd08892
      Location:154277
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:1110
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
    2. NM_001290655.1NP_001277584.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK034661, AK137116, AL672049, CJ147821
      UniProtKB/Swiss-Prot
      Q8N9S3
      Conserved Domains (2) summary
      smart01000
      Location:29158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      cl14643
      Location:202274
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    3. NM_172391.4NP_765979.3  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_765979.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK034661, AK137116, CJ147821
      Consensus CDS
      CCDS24476.1
      UniProtKB/Swiss-Prot
      Q8N9S3
      Related
      ENSMUSP00000020529.6, ENSMUST00000020529.12
      Conserved Domains (3) summary
      cd08892
      Location:202325
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:29158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      COG5580
      Location:20321
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      23487882..23498039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514710.2XP_006514773.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

      Conserved Domains (1) summary
      cd08892
      Location:40163
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    2. XM_011243721.1XP_011242023.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1

      Conserved Domains (2) summary
      smart01000
      Location:29158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      cl14643
      Location:202258
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    3. XM_011243723.1XP_011242025.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_011242025.1

      Conserved Domains (1) summary
      smart01000
      Location:29157
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
    4. XM_011243722.2XP_011242024.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_011242024.1

      Conserved Domains (1) summary
      smart01000
      Location:29157
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
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