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    Ppia peptidylprolyl isomerase A [ Mus musculus (house mouse) ]

    Gene ID: 268373, updated on 20-Jul-2021

    Summary

    Official Symbol
    Ppiaprovided by MGI
    Official Full Name
    peptidylprolyl isomerase Aprovided by MGI
    Primary source
    MGI:MGI:97749
    See related
    Ensembl:ENSMUSG00000071866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cp; Cy; Cphn; CypA; SP18; CyP-1; CyP-18
    Expression
    Ubiquitous expression in liver E14 (RPKM 1110.7), CNS E11.5 (RPKM 1109.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ppia in Genome Data Viewer
    Location:
    11 A1; 11 3.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6365867..6369817)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6415867..6419817)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (6315873..6319813)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene microRNA 7651 Neighboring gene H2A.Z histone variant 2 Neighboring gene 60S ribosomal protein L36a-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparan sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase A
    Names
    PPIase A
    cyclophilin A
    cyclosporin A-binding protein
    rotamase A
    NP_032933.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008907.2NP_032933.1  peptidyl-prolyl cis-trans isomerase A

      See identical proteins and their annotated locations for NP_032933.1

      Status: VALIDATED

      Source sequence(s)
      AK160780
      Consensus CDS
      CCDS24419.1
      UniProtKB/Swiss-Prot
      P17742
      UniProtKB/TrEMBL
      Q5SVY2
      Related
      ENSMUSP00000117987.2, ENSMUST00000132846.2
      Conserved Domains (1) summary
      cd01926
      Location:4162
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6365867..6369817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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