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    Rcn2 reticulocalbin 2 [ Mus musculus (house mouse) ]

    Gene ID: 26611, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rcn2provided by MGI
    Official Full Name
    reticulocalbin 2provided by MGI
    Primary source
    MGI:MGI:1349765
    See related
    Ensembl:ENSMUSG00000032320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TCBP-4; Tcbp49; AA408742
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 45.9), limb E14.5 (RPKM 44.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Rcn2 in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55949129..55966367)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56041845..56059083)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (55889652..55906890)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930563M21 gene Neighboring gene leucine zipper transcription factor-like 1 pseudogene Neighboring gene ring finger protein 19A pseudogene Neighboring gene proline-serine-threonine phosphatase-interacting protein 1 Neighboring gene tetraspanin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    reticulocalbin-2
    Names
    taipoxin-associated calcium binding protein 49

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278274.1NP_001265203.1  reticulocalbin-2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' structure which results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC158999, AK077734
      UniProtKB/TrEMBL
      Q8BP39
      Related
      ENSMUSP00000120953.2, ENSMUST00000147842.2
      Conserved Domains (2) summary
      cd15899
      Location:3261
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:3287
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    2. NM_011992.2NP_036122.2  reticulocalbin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_036122.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158999, AK077486, BB316373, BB638743
      Consensus CDS
      CCDS23206.1
      UniProtKB/Swiss-Prot
      Q8BP92
      Related
      ENSMUSP00000109915.3, ENSMUST00000114276.3
      Conserved Domains (3) summary
      cd00051
      Location:68124
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:194259
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:240293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55949129..55966367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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