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    CKAP2 cytoskeleton associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 26586, updated on 3-Apr-2024

    Summary

    Official Symbol
    CKAP2provided by HGNC
    Official Full Name
    cytoskeleton associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:1990
    See related
    Ensembl:ENSG00000136108 MIM:611569; AllianceGenome:HGNC:1990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LB1; TMAP; se20-10
    Summary
    This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in bone marrow (RPKM 15.6), testis (RPKM 14.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CKAP2 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52455478..52476627)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51670301..51692112)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53029613..53050762)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 homolog Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53024355-53024935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7791 Neighboring gene CKAP2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 345 Neighboring gene TPTE2 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 15313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7793 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10749, DKFZp686L1238

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytoskeleton-associated protein 2
    Names
    CTCL tumor antigen se20-10
    tumor- and microtubule-associated protein
    tumor-associated microtubule-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098525.3NP_001091995.1  cytoskeleton-associated protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001091995.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AI499799, AY062261, EC439890, Y15758
      Consensus CDS
      CCDS41893.1
      UniProtKB/Swiss-Prot
      A2BDE0, A5YM58, B4DR35, E9PD90, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q8WWK9, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4
      UniProtKB/TrEMBL
      B2RMQ4
      Related
      ENSP00000367276.4, ENST00000378037.9
      Conserved Domains (1) summary
      pfam15297
      Location:326673
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    2. NM_001286686.2NP_001273615.1  cytoskeleton-associated protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI499799, AK299083, AY062261, EC439890
      Consensus CDS
      CCDS66557.1
      UniProtKB/TrEMBL
      B2RMQ4
      Related
      ENSP00000417830.1, ENST00000490903.5
      Conserved Domains (1) summary
      pfam15297
      Location:277624
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    3. NM_001286687.2NP_001273616.1  cytoskeleton-associated protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001273616.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as CKAP2-s) lacks multiple 3' coding exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA308726, AY062262
      Consensus CDS
      CCDS73578.1
      UniProtKB/Swiss-Prot
      Q8WWK9
      Related
      ENSP00000367273.2, ENST00000378034.7
      Conserved Domains (1) summary
      pfam15297
      Location:325492
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    4. NM_018204.5NP_060674.3  cytoskeleton-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_060674.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI499799, AK022982, AY062261, EC439890
      Consensus CDS
      CCDS9435.1
      UniProtKB/TrEMBL
      B2RMQ4
      Related
      ENSP00000258607.5, ENST00000258607.10
      Conserved Domains (1) summary
      pfam15297
      Location:325672
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      52455478..52476627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266344.5XP_005266401.1  cytoskeleton-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RMQ4
      Conserved Domains (1) summary
      pfam15297
      Location:278625
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    2. XM_047430268.1XP_047286224.1  cytoskeleton-associated protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      51670301..51692112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374449.1XP_054230424.1  cytoskeleton-associated protein 2 isoform X1

    2. XM_054374450.1XP_054230425.1  cytoskeleton-associated protein 2 isoform X2