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    Homer1 homer scaffolding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 26556, updated on 14-Sep-2021

    Summary

    Official Symbol
    Homer1provided by MGI
    Official Full Name
    homer scaffolding protein 1provided by MGI
    Primary source
    MGI:MGI:1347345
    See related
    Ensembl:ENSMUSG00000007617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ves; PSD-Z; SYN47; Ves-1; vesl-1; homer-1; PSD-Zip45
    Expression
    Broad expression in cortex adult (RPKM 6.9), frontal lobe adult (RPKM 5.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Homer1 in Genome Data Viewer
    Location:
    13; 13 C3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93440265..93549471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93303757..93405129)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (94074450..94174917)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41020 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene family with sequence similarity 113, member B pseudogene Neighboring gene junction-mediating and regulatory protein Neighboring gene predicted gene 6109

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G protein-coupled glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chemical homeostasis within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of store-operated calcium entry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in costamere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in glutamatergic synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    homer protein homolog 1
    Names
    VASP/Ena-related gene up-regulated during seizure and LTP 1
    homer homolog 1
    homer, neuronal immediate early gene, 1
    immediate early gene protein Homer1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284189.2NP_001271118.1  homer protein homolog 1 isoform b

      See identical proteins and their annotated locations for NP_001271118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b, also known as homer-1b) lacks an alternate in-frame exon in the central coding region, compared to variant L. The encoded isoform (b) is shorter than isoform L.
      Source sequence(s)
      AC154231, AF093258, AK137151, BY644449, CJ130737
      Consensus CDS
      CCDS70484.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      UniProtKB/TrEMBL
      Q3UVL6
      Related
      ENSMUSP00000050471.5, ENSMUST00000060490.11
      Conserved Domains (2) summary
      COG1196
      Location:157352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    2. NM_001347598.1NP_001334527.1  homer protein homolog 1 isoform M

      Status: VALIDATED

      Description
      Transcript Variant: This variant (M, also known as Vesl-1M) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant L. The encoded isoform (M) has a shorter and distinct C-terminus, compared to isoform L.
      Source sequence(s)
      AC120347, AK137151, BB448191, CJ130737, CJ133579
      Consensus CDS
      CCDS84048.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      UniProtKB/TrEMBL
      Q3UVL6
      Related
      ENSMUSP00000105118.2, ENSMUST00000109492.9
    3. NM_011982.4NP_036112.1  homer protein homolog 1 isoform S

      See identical proteins and their annotated locations for NP_036112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (S, also known as homer-1a or Vesl-1S) lacks several 3' exons but contains a 3' terminal exon that extends past a splice site that is used in variant L, resulting in a novel 3' coding region and 3' UTR, compared to variant L. The encoded isoform (S) has a shorter and distinct C-terminus, compared to isoform L.
      Source sequence(s)
      AF093257, AK137151, BC064041, CJ130737
      Consensus CDS
      CCDS26687.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      UniProtKB/TrEMBL
      Q3UVL6, Q5D052
      Related
      ENSMUSP00000099813.4, ENSMUST00000102752.10
      Conserved Domains (1) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    4. NM_147176.4NP_671705.2  homer protein homolog 1 isoform L

      See identical proteins and their annotated locations for NP_671705.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (L, also known as Vesl-1L) represents the longest transcript and encodes isoform L.
      Source sequence(s)
      AB019479, AC154231, AF093258, AK137151, BY644449, CJ130737
      Consensus CDS
      CCDS36745.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      UniProtKB/TrEMBL
      Q3UVL6
      Related
      ENSMUSP00000079026.6, ENSMUST00000080127.12
      Conserved Domains (2) summary
      COG1196
      Location:187364
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    5. NM_152134.3NP_687036.1  homer protein homolog 1 isoform d

      See identical proteins and their annotated locations for NP_687036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d, also known as homer-1d) uses an alternate 5'-terminal exon, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant L. The encoded isoform (d) has a distinct N-terminus and is longer than isoform L.
      Source sequence(s)
      AC120347, AC154231, AF093258
      Consensus CDS
      CCDS36746.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      Related
      ENSMUSP00000078093.7, ENSMUST00000079086.8
      Conserved Domains (3) summary
      cd01206
      Location:19127
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl12013
      Location:206349
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19219
      Location:264334
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      93440265..93549471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158052.1XP_036013945.1  homer protein homolog 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:203380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:19127
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    2. XM_036158053.1XP_036013946.1  homer protein homolog 1 isoform X2

      Conserved Domains (1) summary
      cd01206
      Location:19127
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
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