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    Cul3 cullin 3 [ Mus musculus (house mouse) ]

    Gene ID: 26554, updated on 12-Mar-2019

    Summary

    Official Symbol
    Cul3provided by MGI
    Official Full Name
    cullin 3provided by MGI
    Primary source
    MGI:MGI:1347360
    See related
    Ensembl:ENSMUSG00000004364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KIAA0617
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 16.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See Cul3 in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (80264923..80340690, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (80263393..80337005, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108167342 Neighboring gene RIKEN cDNA 2310015K22 gene Neighboring gene family with sequence similarity 124, member B Neighboring gene predicted gene, 34098 Neighboring gene predicted gene, 39667 Neighboring gene GLE1 RNA export mediator pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Notch binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    POZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
     
    ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear protein quality control by the ubiquitin-proteasome system ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    trophectodermal cellular morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polar microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313728.1NP_001300657.1  cullin-3 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter, distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC161416, AC166157, AF129738, AK003885, AK034695, BE991461, BM899470, CK634506
      UniProtKB/Swiss-Prot
      Q9JLV5
      UniProtKB/TrEMBL
      Q9CTE0
      Conserved Domains (3) summary
      smart00182
      Location:370512
      CULLIN; Cullin
      pfam00888
      Location:37613
      Cullin; Cullin family
      pfam10557
      Location:649709
      Cullin_Nedd8; Cullin protein neddylation domain
    2. NM_016716.5NP_057925.1  cullin-3 isoform 1

      See identical proteins and their annotated locations for NP_057925.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161416, AF129738, AK003885, AK034695, BE991461, BM899470
      Consensus CDS
      CCDS15094.1
      UniProtKB/Swiss-Prot
      Q9JLV5
      UniProtKB/TrEMBL
      Q9CTE0
      Related
      ENSMUSP00000130738.1, ENSMUST00000163119.7
      Conserved Domains (3) summary
      smart00182
      Location:421563
      CULLIN; Cullin
      pfam00888
      Location:35664
      Cullin; Cullin family
      pfam10557
      Location:700760
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      80264923..80340690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496498.3XP_006496561.1  cullin-3 isoform X2

      Related
      ENSMUSP00000131891.1, ENSMUST00000164108.7
      Conserved Domains (3) summary
      smart00182
      Location:340482
      CULLIN; Cullin
      pfam00888
      Location:6583
      Cullin; Cullin family
      pfam10557
      Location:619679
      Cullin_Nedd8; Cullin protein neddylation domain
    2. XM_006496497.3XP_006496560.1  cullin-3 isoform X1

      Conserved Domains (3) summary
      smart00182
      Location:343485
      CULLIN; Cullin
      pfam00888
      Location:5586
      Cullin; Cullin family
      pfam10557
      Location:622682
      Cullin_Nedd8; Cullin protein neddylation domain
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