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    IL36RN interleukin 36 receptor antagonist [ Homo sapiens (human) ]

    Gene ID: 26525, updated on 8-Jul-2021

    Summary

    Official Symbol
    IL36RNprovided by HGNC
    Official Full Name
    interleukin 36 receptor antagonistprovided by HGNC
    Primary source
    HGNC:HGNC:15561
    See related
    Ensembl:ENSG00000136695 MIM:605507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 14.6), esophagus (RPKM 6.5) and 1 other tissue See more
    Orthologs
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    Genomic context

    See IL36RN in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113058638..113064744)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113816215..113822321)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 36 alpha Neighboring gene interleukin 36 beta Neighboring gene interleukin 1 family member 10 Neighboring gene RNA, U6 small nuclear 1180, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29840

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-1 receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-36 receptor antagonist protein
    Names
    IL-1 related protein 3
    IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)
    IL-1ra homolog 1
    IL1F5 (Canonical product IL-1F5a)
    interleukin 1 family, member 5 (delta)
    interleukin-1 HY1
    interleukin-1 receptor antagonist homolog 1
    interleukin-1-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031864.1 RefSeqGene

      Range
      5001..11107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_730

    mRNA and Protein(s)

    1. NM_012275.3NP_036407.1  interleukin-36 receptor antagonist protein

      See identical proteins and their annotated locations for NP_036407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC016724, AF186094
      Consensus CDS
      CCDS2111.1
      UniProtKB/Swiss-Prot
      Q9UBH0
      UniProtKB/TrEMBL
      A0A024R518
      Related
      ENSP00000376896.2, ENST00000393200.7
      Conserved Domains (1) summary
      cl00094
      Location:9152
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_173170.1NP_775262.1  interleukin-36 receptor antagonist protein

      See identical proteins and their annotated locations for NP_775262.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC016724, AF186094, BC024747
      Consensus CDS
      CCDS2111.1
      UniProtKB/Swiss-Prot
      Q9UBH0
      UniProtKB/TrEMBL
      A0A024R518
      Related
      ENSP00000259212.3, ENST00000346807.7
      Conserved Domains (1) summary
      cl00094
      Location:9152
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      113058638..113064744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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