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    Psma6 proteasome subunit alpha 6 [ Mus musculus (house mouse) ]

    Gene ID: 26443, updated on 23-Jun-2021

    Summary

    Official Symbol
    Psma6provided by MGI
    Official Full Name
    proteasome subunit alpha 6provided by MGI
    Primary source
    MGI:MGI:1347006
    See related
    Ensembl:ENSMUSG00000021024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IOTA
    Expression
    Ubiquitous expression in testis adult (RPKM 121.3), placenta adult (RPKM 65.6) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Psma6 in Genome Data Viewer
    Location:
    12; 12 C1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55431007..55465244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55384222..55418459)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56499812..56519446)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54C Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene protein only RNase P catalytic subunit Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of polysome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proteasome core complex, alpha-subunit complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-6
    Names
    macropain iota chain
    multicatalytic endopeptidase complex iota chain
    proteasome (prosome, macropain) subunit, alpha type 6
    proteasome iota chain
    NP_001297512.1
    NP_036098.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310583.1NP_001297512.1  proteasome subunit alpha type-6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC159636
      Consensus CDS
      CCDS79114.1
      UniProtKB/TrEMBL
      E0CXB1
      Related
      ENSMUSP00000124781.2, ENSMUST00000163070.8
      Conserved Domains (1) summary
      cd03754
      Location:8201
      proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    2. NM_011968.3NP_036098.1  proteasome subunit alpha type-6 isoform 1

      See identical proteins and their annotated locations for NP_036098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AV265469, BC086685, BY340104
      Consensus CDS
      CCDS25917.1
      UniProtKB/Swiss-Prot
      Q9QUM9
      Related
      ENSMUSP00000021412.9, ENSMUST00000021412.9
      Conserved Domains (1) summary
      cd03754
      Location:8220
      proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55431007..55465244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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