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    Psma6 proteasome (prosome, macropain) subunit, alpha type 6 [ Mus musculus (house mouse) ]

    Gene ID: 26443, updated on 9-Sep-2018

    Summary

    Official Symbol
    Psma6provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, alpha type 6provided by MGI
    Primary source
    MGI:MGI:1347006
    See related
    Ensembl:ENSMUSG00000021024 Vega:OTTMUSG00000034926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IOTA
    Expression
    Ubiquitous expression in testis adult (RPKM 121.3), placenta adult (RPKM 65.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See Psma6 in Genome Data Viewer
    Location:
    12; 12 C1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (55384222..55418459)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56499812..56519446)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54C Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene RIKEN cDNA 1110008L16 gene Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle tissue development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    polysome ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome core complex, alpha-subunit complex ISO
    Inferred from Sequence Orthology
    more info
     
    sarcomere ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-6
    Names
    macropain iota chain
    multicatalytic endopeptidase complex iota chain
    proteasome iota chain
    NP_001297512.1
    NP_036098.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310583.1NP_001297512.1  proteasome subunit alpha type-6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC159636
      Consensus CDS
      CCDS79114.1
      UniProtKB/TrEMBL
      E0CXB1
      Related
      ENSMUSP00000124781.1, OTTMUSP00000048452, ENSMUST00000163070.7, OTTMUST00000088809
      Conserved Domains (1) summary
      cd03754
      Location:8201
      proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    2. NM_011968.3NP_036098.1  proteasome subunit alpha type-6 isoform 1

      See identical proteins and their annotated locations for NP_036098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AV265469, BC086685, BY340104
      Consensus CDS
      CCDS25917.1
      UniProtKB/Swiss-Prot
      Q9QUM9
      Related
      ENSMUSP00000021412.8, OTTMUSP00000048451, ENSMUST00000021412.8, OTTMUST00000088808
      Conserved Domains (1) summary
      cd03754
      Location:8220
      proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      55384222..55418459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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