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    Parg poly (ADP-ribose) glycohydrolase [ Mus musculus (house mouse) ]

    Gene ID: 26430, updated on 12-Aug-2018

    Summary

    Official Symbol
    Pargprovided by MGI
    Official Full Name
    poly (ADP-ribose) glycohydrolaseprovided by MGI
    Primary source
    MGI:MGI:1347094
    See related
    Ensembl:ENSMUSG00000021911 Vega:OTTMUSG00000036550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI413217
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 3.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Parg in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (32201971..32298657)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (33015157..33110736)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 4 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene predicted gene, 46447 Neighboring gene oxoglutarate dehydrogenase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(ADP-ribose) glycohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly(ADP-ribose) glycohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    poly(ADP-ribose) glycohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ATP generation from poly-ADP-D-ribose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide-sugar metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    poly(ADP-ribose) glycohydrolase
    Names
    cytosolic poly(ADP-ribose) glycohydrolase
    mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform
    NP_036090.2
    XP_011243373.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359915.1NP_001346844.1  poly(ADP-ribose) glycohydrolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167565, AI450246, AK080306, BC053037, BC059827
      Conserved Domains (1) summary
      pfam05028
      Location:491819
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    2. NM_011960.3NP_036090.2  poly(ADP-ribose) glycohydrolase isoform 1

      See identical proteins and their annotated locations for NP_036090.2

      Status: VALIDATED

      Source sequence(s)
      AC167565, AI450246, BC053037, BC059827
      Consensus CDS
      CCDS36865.1
      UniProtKB/TrEMBL
      G3X8U8
      Related
      ENSMUSP00000022470.8, OTTMUSP00000052065, ENSMUST00000022470.14
      Conserved Domains (1) summary
      pfam05028
      Location:574902
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      32201971..32298657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245071.2XP_011243373.1  poly(ADP-ribose) glycohydrolase isoform X1

      Conserved Domains (1) summary
      pfam05028
      Location:491819
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
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