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    Parg poly (ADP-ribose) glycohydrolase [ Mus musculus (house mouse) ]

    Gene ID: 26430, updated on 8-Jul-2021

    Summary

    Official Symbol
    Pargprovided by MGI
    Official Full Name
    poly (ADP-ribose) glycohydrolaseprovided by MGI
    Primary source
    MGI:MGI:1347094
    See related
    Ensembl:ENSMUSG00000021911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI413217
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 3.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Parg in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31923900..32020671)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32201930..32298714)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (33015157..33110736)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 4 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946 Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene predicted gene, 48914 Neighboring gene oxoglutarate dehydrogenase-like Neighboring gene predicted gene, 52134 Neighboring gene RIKEN cDNA 1700024G13 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-amino-acid esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(ADP-ribose) glycohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(ADP-ribose) glycohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables poly(ADP-ribose) glycohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleotide-sugar metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of histone modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    poly(ADP-ribose) glycohydrolase
    Names
    cytosolic poly(ADP-ribose) glycohydrolase
    NP_001346844.1
    NP_001361150.1
    NP_036090.2
    XP_030103682.1
    XP_030103683.1
    XP_036014496.1
    XP_036014497.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359915.1NP_001346844.1  poly(ADP-ribose) glycohydrolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167565, AI450246, AK080306, BC053037, BC059827
      Conserved Domains (1) summary
      pfam05028
      Location:491816
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    2. NM_001374221.1NP_001361150.1  poly(ADP-ribose) glycohydrolase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532, AC167565
      Conserved Domains (1) summary
      pfam05028
      Location:468793
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    3. NM_011960.3NP_036090.2  poly(ADP-ribose) glycohydrolase isoform 1

      See identical proteins and their annotated locations for NP_036090.2

      Status: VALIDATED

      Source sequence(s)
      AC167565, AI450246, BC053037, BC059827
      Consensus CDS
      CCDS36865.1
      UniProtKB/TrEMBL
      G3X8U8
      Related
      ENSMUSP00000022470.9, ENSMUST00000022470.15
      Conserved Domains (1) summary
      pfam05028
      Location:574902
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31923900..32020671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158604.1XP_036014497.1  poly(ADP-ribose) glycohydrolase isoform X3

      Related
      ENSMUSP00000154704.2, ENSMUST00000164137.8
      Conserved Domains (2) summary
      pfam05028
      Location:574682
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
      NF033845
      Location:171346
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    2. XM_036158603.1XP_036014496.1  poly(ADP-ribose) glycohydrolase isoform X1

      Conserved Domains (1) summary
      pfam05028
      Location:491816
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    3. XM_030247822.2XP_030103682.1  poly(ADP-ribose) glycohydrolase isoform X1

      Conserved Domains (1) summary
      pfam05028
      Location:491816
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    4. XM_030247823.2XP_030103683.1  poly(ADP-ribose) glycohydrolase isoform X2

      Conserved Domains (1) summary
      pfam05028
      Location:468793
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
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