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    Nr5a2 nuclear receptor subfamily 5, group A, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 26424, updated on 6-Nov-2018

    Summary

    Official Symbol
    Nr5a2provided by MGI
    Official Full Name
    nuclear receptor subfamily 5, group A, member 2provided by MGI
    Primary source
    MGI:MGI:1346834
    See related
    Ensembl:ENSMUSG00000026398 Vega:OTTMUSG00000049882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftf; LRH-1; UF2-H3B; AU020803; D1Ertd308e
    Expression
    Biased expression in ovary adult (RPKM 23.7), liver adult (RPKM 4.6) and 7 other tissues See more
    Orthologs

    Genomic context

    See Nr5a2 in Genome Data Viewer
    Location:
    1 59.98 cM; 1 E4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (136842562..136960448, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (138740161..138857025, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase pseudogene Neighboring gene uncharacterized protein C1orf43 homolog Neighboring gene U7 small nuclear RNA, pseudogene 3 Neighboring gene COP9 (constitutive photomorphogenic) homolog, subunit 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bile acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcineurin-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pancreas morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear receptor subfamily 5 group A member 2
    Names
    fetoprotein transcription factor
    liver receptor homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159769.2NP_001153241.1  nuclear receptor subfamily 5 group A member 2 isoform 2

      See identical proteins and their annotated locations for NP_001153241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) contains a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124814
      Consensus CDS
      CCDS48382.1
      UniProtKB/TrEMBL
      Q1WLP7
      Related
      ENSMUSP00000141495.1, OTTMUSP00000068639, ENSMUST00000192929.5, OTTMUST00000127013
      Conserved Domains (2) summary
      cd07069
      Location:259499
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:46138
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    2. NM_030676.3NP_109601.1  nuclear receptor subfamily 5 group A member 2 isoform 1

      See identical proteins and their annotated locations for NP_109601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC120182, AC124814, BC137845
      Consensus CDS
      CCDS15328.1
      UniProtKB/Swiss-Prot
      P45448
      Related
      ENSMUSP00000027649.7, OTTMUSP00000068636, ENSMUST00000027649.13, OTTMUST00000127010
      Conserved Domains (2) summary
      cd07069
      Location:320560
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:107199
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      136842562..136960448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529621.3XP_006529684.1  nuclear receptor subfamily 5 group A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YY04
      Related
      ENSMUSP00000142219.1, OTTMUSP00000068638, ENSMUST00000192357.5, OTTMUST00000127012
      Conserved Domains (2) summary
      cd07069
      Location:299539
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:86178
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    2. XM_006529622.3XP_006529685.1  nuclear receptor subfamily 5 group A member 2 isoform X2

      See identical proteins and their annotated locations for XP_006529685.1

      UniProtKB/TrEMBL
      Q1WLP7
      Related
      ENSMUSP00000129071.1, OTTMUSP00000068637, ENSMUST00000168126.6, OTTMUST00000127011
      Conserved Domains (2) summary
      cd07069
      Location:259499
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:46138
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
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