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    Mapk9 mitogen-activated protein kinase 9 [ Mus musculus (house mouse) ]

    Gene ID: 26420, updated on 14-Sep-2021

    Summary

    Official Symbol
    Mapk9provided by MGI
    Official Full Name
    mitogen-activated protein kinase 9provided by MGI
    Primary source
    MGI:MGI:1346862
    See related
    Ensembl:ENSMUSG00000020366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JNK; Prk; JNK2; Prkm9; AI851083; p54aSAPK
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 32.4), cortex adult (RPKM 26.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mapk9 in Genome Data Viewer
    Location:
    11; 11 B1.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49737558..49777248)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49846728..49886421)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (49660253..49699923)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36411 Neighboring gene predicted gene, 36507 Neighboring gene glutamine fructose-6-phosphate transaminase 2 Neighboring gene RasGEF domain family, member 1C Neighboring gene predicted gene, 53699 Neighboring gene ring finger protein 130 Neighboring gene microRNA 340

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in JUN phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell morphogenesis involved in differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription factor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to tricellular tight junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cadmium ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 9
    Names
    JNK/SAPK alpha
    Jun kinase
    MAP kinase 9
    MAPK 9
    c-Jun N-terminal kinase 2
    protein kinase, mitogen-activated 9
    stress-activated protein kinase JNK2
    NP_001157143.1
    NP_001157144.1
    NP_058657.1
    NP_997575.2
    XP_017170051.1
    XP_017170052.1
    XP_030101882.1
    XP_030101883.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163671.1NP_001157143.1  mitogen-activated protein kinase 9 isoform beta2

      See identical proteins and their annotated locations for NP_001157143.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (beta2) contains an alternate in-frame coding exon of the same length compared to variant alpha2. This results in an isoform (beta2) of the same length, but with a different internal protein segment compared to isoform alpha2.
      Source sequence(s)
      AK031959, AK031974, BB362351, CX235052
      Consensus CDS
      CCDS48782.1
      UniProtKB/Swiss-Prot
      Q9WTU6
      UniProtKB/TrEMBL
      Q8C094
      Related
      ENSMUSP00000136977.2, ENSMUST00000178543.8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001163672.1NP_001157144.1  mitogen-activated protein kinase 9 isoform alpha1

      See identical proteins and their annotated locations for NP_001157144.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (alpha1) uses an alternate acceptor splice site at the 3' terminal exon compared to variant alpha2. This causes a frameshift and early translation termination, resulting in a shorter isoform (alpha1) with a distinct C-terminus compared to isoform alpha2.
      Source sequence(s)
      AK031959, AK031974, BB362351, CX235052
      Consensus CDS
      CCDS48783.1
      UniProtKB/Swiss-Prot
      Q9WTU6
      UniProtKB/TrEMBL
      Q8C094
      Related
      ENSMUSP00000132864.2, ENSMUST00000164643.8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. NM_016961.3NP_058657.1  mitogen-activated protein kinase 9 isoform beta1

      See identical proteins and their annotated locations for NP_058657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (beta1) contains an alternate in-frame coding exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant alpha2. This results in a shorter isoform (beta1) with a different internal protein segment, and with a distinct C-terminus compared to isoform alpha2.
      Source sequence(s)
      AK031959, AK031974, BB362351, CX235052
      Consensus CDS
      CCDS24624.1
      UniProtKB/Swiss-Prot
      Q9WTU6
      UniProtKB/TrEMBL
      Q8C094
      Related
      ENSMUSP00000104808.3, ENSMUST00000109179.9
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. NM_207692.2NP_997575.2  mitogen-activated protein kinase 9 isoform alpha2

      See identical proteins and their annotated locations for NP_997575.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (alpha2) encodes isoform alpha2.
      Source sequence(s)
      AK031959, AK031974, BB362351, CX235052
      Consensus CDS
      CCDS24623.1
      UniProtKB/Swiss-Prot
      Q9WTU6
      UniProtKB/TrEMBL
      Q5NCK8, Q8C094
      Related
      ENSMUSP00000020634.8, ENSMUST00000020634.14
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49737558..49777248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246023.2XP_030101883.1  mitogen-activated protein kinase 9 isoform X4

      Conserved Domains (1) summary
      cd07850
      Location:16334
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. XM_017314563.3XP_017170052.1  mitogen-activated protein kinase 9 isoform X2

      Conserved Domains (1) summary
      cd07850
      Location:16334
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. XM_017314562.3XP_017170051.1  mitogen-activated protein kinase 9 isoform X1

      Conserved Domains (1) summary
      cd07850
      Location:16334
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. XM_030246022.2XP_030101882.1  mitogen-activated protein kinase 9 isoform X3

      Conserved Domains (1) summary
      cd07850
      Location:16334
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
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