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    GCGR glucagon receptor [ Homo sapiens (human) ]

    Gene ID: 2642, updated on 11-Jun-2021

    Summary

    Official Symbol
    GCGRprovided by HGNC
    Official Full Name
    glucagon receptorprovided by HGNC
    Primary source
    HGNC:HGNC:4192
    See related
    Ensembl:ENSG00000215644 MIM:138033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GGR; GL-R; MVAH
    Summary
    The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
    Expression
    Biased expression in liver (RPKM 10.3), kidney (RPKM 5.0) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GCGR in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81804078..81814008)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79762026..79771884)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 10 Neighboring gene uncharacterized LOC105371929 Neighboring gene uncharacterized LOC105376789 Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene MAPK regulated corepressor interacting protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ97182, MGC138246

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucagon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucagon receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucagon stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of glycogen metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nutrient TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016409.1 RefSeqGene

      Range
      2977..12835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000160.5NP_000151.1  glucagon receptor precursor

      See identical proteins and their annotated locations for NP_000151.1

      Status: REVIEWED

      Source sequence(s)
      BC104854, DA639395, L20316, U03469
      Consensus CDS
      CCDS54177.1
      UniProtKB/Swiss-Prot
      P47871
      Related
      ENSP00000383558.3, ENST00000400723.8
      Conserved Domains (2) summary
      pfam02793
      Location:55122
      HRM; Hormone receptor domain
      cd15267
      Location:136410
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      81804078..81814008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024446.1XP_016879935.1  glucagon receptor isoform X2

    2. XM_011523539.1XP_011521841.1  glucagon receptor isoform X3

      Conserved Domains (1) summary
      pfam00002
      Location:105363
      7tm_2; 7 transmembrane receptor (Secretin family)
    3. XM_006722277.1XP_006722340.1  glucagon receptor isoform X1

      See identical proteins and their annotated locations for XP_006722340.1

      UniProtKB/Swiss-Prot
      P47871
      Conserved Domains (2) summary
      pfam02793
      Location:55122
      HRM; Hormone receptor domain
      cd15267
      Location:136410
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    4. XM_017024447.1XP_016879936.1  glucagon receptor isoform X4

      Conserved Domains (1) summary
      pfam00002
      Location:16274
      7tm_2; 7 transmembrane receptor (Secretin family)

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_021160021.1 Reference GRCh38.p13 PATCHES

      Range
      17643..27501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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