Format

Send to:

Choose Destination
    • Showing Current items.

    Mapk8 mitogen-activated protein kinase 8 [ Mus musculus (house mouse) ]

    Gene ID: 26419, updated on 17-Aug-2021

    Summary

    Official Symbol
    Mapk8provided by MGI
    Official Full Name
    mitogen-activated protein kinase 8provided by MGI
    Primary source
    MGI:MGI:1346861
    See related
    Ensembl:ENSMUSG00000021936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JNK; Prk; JNK1; Prkm8; SAPK1; AI849689
    Expression
    Broad expression in CNS E18 (RPKM 19.1), CNS E14 (RPKM 18.4) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mapk8 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33099855..33169215, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33377898..33447353, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (34191084..34260344, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 22 Neighboring gene predicted pseudogene 6340 Neighboring gene predicted gene, 41130 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within JUN phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within JUN phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to biotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of dorsal identity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of determination of dorsal identity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription factor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within programmed necrotic cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to tricellular tight junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dense core granule transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cadmium ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 8
    Names
    JNK1 beta1 protein kinase
    MAP kinase 8
    MAPK 8
    c-Jun N-terminal kinase 1
    protein kinase mitogen-activated 8
    stress-activated protein kinase JNK1
    NP_001297381.1
    NP_001297382.1
    NP_001297383.1
    NP_057909.1
    XP_006519095.1
    XP_030103680.1
    XP_030103681.1
    XP_036014495.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310452.1NP_001297381.1  mitogen-activated protein kinase 8 isoform 2

      See identical proteins and their annotated locations for NP_001297381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and both contains and lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2 which is the same length as isoform 1, but differs in a small segment in the central region of the protein, compared to isoform 1.
      Source sequence(s)
      AI849689, AK039129, AK047936, AK139498, BC053027, CD803749
      Consensus CDS
      CCDS84111.1
      UniProtKB/TrEMBL
      A6P3E4, Q7TSJ7
      Related
      ENSMUSP00000107574.2, ENSMUST00000111943.8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001310453.1NP_001297382.1  mitogen-activated protein kinase 8 isoform 4

      See identical proteins and their annotated locations for NP_001297382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) both contains and lacks an alternate in-frame exon in the central coding region, and uses an alternate splice donor site in its 3' terminal exon which results in a frameshift, compared to variant 1. It encodes isoform 4 has an alternate region in the central region of the protein and a longer and distinct C-terminus, compared to isoform 1. Isoforms 3 and 4 are the same length, but differ in a small segment in the central region of the protein.
      Source sequence(s)
      AI849689, AK030767, AK039129, AK047936, AK139498, BC053027
      Consensus CDS
      CCDS79293.1
      UniProtKB/TrEMBL
      G3X8U9, Q7TSJ7
      Related
      ENSMUSP00000022504.6, ENSMUST00000022504.12
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. NM_001310454.1NP_001297383.1  mitogen-activated protein kinase 8 isoform 3

      See identical proteins and their annotated locations for NP_001297383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice donor site in its 3' terminal exon which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1. Isoforms 3 and 4 are the same length, but differ in a small segment in the central region of the protein.
      Source sequence(s)
      AI849689, AK030767, AK039129, AK047936, BC053027
      Consensus CDS
      CCDS79295.1
      UniProtKB/TrEMBL
      Q7TSJ7
      Related
      ENSMUSP00000107575.4, ENSMUST00000111944.10
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. NM_016700.4NP_057909.1  mitogen-activated protein kinase 8 isoform 1

      See identical proteins and their annotated locations for NP_057909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Isoforms 1 and 2 are the same length, but differ in a small segment in the central region of the protein.
      Source sequence(s)
      AI849689, AK043102, AK047936, AK053062, AK162915, BB619635
      Consensus CDS
      CCDS36869.1
      UniProtKB/Swiss-Prot
      Q91Y86
      UniProtKB/TrEMBL
      Q544A0
      Related
      ENSMUSP00000107576.3, ENSMUST00000111945.9
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33099855..33169215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519032.5XP_006519095.1  mitogen-activated protein kinase 8 isoform X1

      See identical proteins and their annotated locations for XP_006519095.1

      UniProtKB/TrEMBL
      A6P3E4
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. XM_030247821.2XP_030103681.1  mitogen-activated protein kinase 8 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036158602.1XP_036014495.1  mitogen-activated protein kinase 8 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    4. XM_030247820.2XP_030103680.1  mitogen-activated protein kinase 8 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    Support Center