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    Mapk1 mitogen-activated protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 26413, updated on 5-Mar-2019

    Summary

    Official Symbol
    Mapk1provided by MGI
    Official Full Name
    mitogen-activated protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1346858
    See related
    Ensembl:ENSMUSG00000063358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERK; Erk2; MAPK2; PRKM2; Prkm1; C78273; p41mapk; p42mapk; AA407128; AU018647; 9030612K14Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mapk1 in Genome Data Viewer
    Location:
    16 A3; 16 10.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (16983379..17047453)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (16983475..17047546)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene Neighboring gene predicted gene 6438 Neighboring gene yippee like 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Bergmann glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ERBB signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac neural crest cell development involved in heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    caveolin-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to dopamine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytosine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    diadenosine tetraphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    face development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mammary gland epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neural crest cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    outer ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of Golgi inheritance TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of early endosome to late endosome transport TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    response to epidermal growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    response to exogenous dsRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    trachea formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    late endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 1
    Names
    ERK-2
    ERT1
    MAP kinase 1
    MAP kinase 2
    MAP kinase isoform p42
    MAPK 1
    MAPK 2
    extracellular signal-regulated kinase 2
    mitogen-activated protein kinase 2
    p42-MAPK
    NP_001033752.1
    NP_036079.1
    XP_006522210.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038663.1NP_001033752.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_001033752.1

      Status: VALIDATED

      Source sequence(s)
      BB648734, D10939
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P63085
      Related
      ENSMUSP00000111396.1, ENSMUST00000115731.9
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    2. NM_001357115.1NP_001344044.1  mitogen-activated protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      AC166346, AC166832
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    3. NM_011949.3NP_036079.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_036079.1

      Status: VALIDATED

      Source sequence(s)
      AC154667, AK132241, BB648734
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P63085
      Related
      ENSMUSP00000065983.7, ENSMUST00000069107.13
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      16983379..17047453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522147.3XP_006522210.1  mitogen-activated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      P63085
      Related
      ENSMUSP00000156154.1, ENSMUST00000232611.1
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
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