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    Mapk1 mitogen-activated protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 26413, updated on 19-Sep-2021

    Summary

    Official Symbol
    Mapk1provided by MGI
    Official Full Name
    mitogen-activated protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1346858
    See related
    Ensembl:ENSMUSG00000063358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERK; MAP; Prk; Erk2; p42m; MAPK2; PRKM2; Prkm1; C78273; p41mapk; p42mapk; AA407128; AU018647; 9030612K14Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mapk1 in Genome Data Viewer
    Location:
    16 A3; 16 10.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16801246..16865317)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16983382..17047453)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (16983475..17047546)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene Neighboring gene predicted gene 6438 Neighboring gene yippee like 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Bergmann glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ERBB signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in aging ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac neural crest cell development involved in heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in caveolin-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dopamine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cytosine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diadenosine tetraphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within face development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neural crest cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within outer ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of macrophage proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of Golgi inheritance TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of early endosome to late endosome transport TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to epidermal growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to exogenous dsRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within trachea formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in late endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 1
    Names
    ERK-2
    ERT1
    MAP kinase 1
    MAP kinase 2
    MAPK 1
    MAPK 2
    extracellular signal-regulated kinase 2
    mitogen-activated protein kinase 2
    p42-MAPK
    NP_001033752.1
    NP_001344044.1
    NP_036079.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038663.1NP_001033752.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_001033752.1

      Status: VALIDATED

      Source sequence(s)
      BB648734, D10939
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P63085
      Related
      ENSMUSP00000111396.2, ENSMUST00000115731.10
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    2. NM_001357115.1NP_001344044.1  mitogen-activated protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      AC166346, AC166832
      Consensus CDS
      CCDS27992.1
      Related
      ENSMUSP00000156154.2, ENSMUST00000232611.2
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    3. NM_011949.3NP_036079.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_036079.1

      Status: VALIDATED

      Source sequence(s)
      AC154667, AK132241, BB648734
      Consensus CDS
      CCDS27992.1
      UniProtKB/Swiss-Prot
      P63085
      Related
      ENSMUSP00000065983.8, ENSMUST00000069107.14
      Conserved Domains (1) summary
      cd07849
      Location:17351
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16801246..16865317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028991.1: Suppressed sequence

      Description
      NM_028991.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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