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    Cdk8 cyclin-dependent kinase 8 [ Mus musculus (house mouse) ]

    Gene ID: 264064, updated on 5-Mar-2019

    Summary

    Official Symbol
    Cdk8provided by MGI
    Official Full Name
    cyclin-dependent kinase 8provided by MGI
    Primary source
    MGI:MGI:1196224
    See related
    Ensembl:ENSMUSG00000029635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 18.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdk8 in Genome Data Viewer
    Location:
    5; 5 G3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (146230802..146302874)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (147043251..147114450)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ring finger protein (C3H2C3 type) 6 Neighboring gene predicted gene, 38745 Neighboring gene predicted gene, 38747 Neighboring gene WAS protein family, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37111

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mediator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 8
    Names
    cell division protein kinase 8
    mediator complex subunit CDK8
    mediator of RNA polymerase II transcription subunit CDK8
    NP_705827.2
    XP_006504898.1
    XP_006504899.1
    XP_006504901.1
    XP_006504902.1
    XP_006504903.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359990.1NP_001346919.1  cyclin-dependent kinase 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC113316
      Conserved Domains (1) summary
      cd07868
      Location:3335
      STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8
    2. NM_001359991.1NP_001346920.1  cyclin-dependent kinase 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC113316, AK131948
      Conserved Domains (1) summary
      cl21453
      Location:1270
      PKc_like; Protein Kinases, catalytic domain
    3. NM_153599.4NP_705827.2  cyclin-dependent kinase 8 isoform 1

      See identical proteins and their annotated locations for NP_705827.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC113316
      Consensus CDS
      CCDS19869.1
      UniProtKB/Swiss-Prot
      Q8R3L8
      Related
      ENSMUSP00000031640.8, ENSMUST00000031640.14
      Conserved Domains (1) summary
      cd07868
      Location:3335
      STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      146230802..146302874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504835.3XP_006504898.1  cyclin-dependent kinase 8 isoform X1

      Conserved Domains (1) summary
      cd07868
      Location:3335
      STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8
    2. XM_006504836.3XP_006504899.1  cyclin-dependent kinase 8 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3L8
      Conserved Domains (2) summary
      smart00220
      Location:22330
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3330
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006504840.3XP_006504903.1  cyclin-dependent kinase 8 isoform X5

      Conserved Domains (2) summary
      smart00220
      Location:22287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3287
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006504838.3XP_006504901.1  cyclin-dependent kinase 8 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:3322
      PKc_like; Protein Kinases, catalytic domain
    5. XM_006504839.3XP_006504902.1  cyclin-dependent kinase 8 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:22298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3298
      PKc_like; Protein Kinases, catalytic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181570.1: Suppressed sequence

      Description
      NM_181570.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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