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    Map3k11 mitogen-activated protein kinase kinase kinase 11 [ Mus musculus (house mouse) ]

    Gene ID: 26403, updated on 22-Aug-2021

    Summary

    Official Symbol
    Map3k11provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 11provided by MGI
    Primary source
    MGI:MGI:1346880
    See related
    Ensembl:ENSMUSG00000004054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlk; Mlk3; PTK1; SPRK; 2610017K16Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 55.6), duodenum adult (RPKM 45.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Map3k11 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5738439..5752893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5688411..5702865)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5689131..5702865)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation associated gene 1 Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene potassium channel, subfamily K, member 7 Neighboring gene EH domain binding protein 1-like 1 Neighboring gene family with sequence similarity 89, member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables JUN kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 11
    Names
    mixed lineage kinase 3
    NP_071295.2
    XP_006531815.1
    XP_006531816.1
    XP_030106811.1
    XP_030106812.1
    XP_030106813.1
    XP_036017492.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022012.3NP_071295.2  mitogen-activated protein kinase kinase kinase 11

      See identical proteins and their annotated locations for NP_071295.2

      Status: PROVISIONAL

      Source sequence(s)
      BC095963
      Consensus CDS
      CCDS29476.1
      UniProtKB/Swiss-Prot
      Q80XI6
      Related
      ENSMUSP00000004156.9, ENSMUST00000004156.10
      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5738439..5752893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250953.1XP_030106813.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3
    2. XM_030250951.2XP_030106811.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3
    3. XM_030250952.1XP_030106812.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3
    4. XM_006531752.2XP_006531815.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

      See identical proteins and their annotated locations for XP_006531815.1

      UniProtKB/Swiss-Prot
      Q80XI6
      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3
    5. XM_036161599.1XP_036017492.1  mitogen-activated protein kinase kinase kinase 11 isoform X1

      Conserved Domains (2) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3
    6. XM_006531753.5XP_006531816.1  mitogen-activated protein kinase kinase kinase 11 isoform X2

      Conserved Domains (3) summary
      PHA03307
      Location:310574
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0419
      Location:118205
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:1122
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004940149.1 RNA Sequence

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