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    Map2k4 mitogen-activated protein kinase kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 26398, updated on 22-Aug-2021

    Summary

    Official Symbol
    Map2k4provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase 4provided by MGI
    Primary source
    MGI:MGI:1346869
    See related
    Ensembl:ENSMUSG00000033352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sek; Ser; JNKK; MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4; MAPKK 4
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 18.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map2k4 in Genome Data Viewer
    Location:
    11 B3; 11 40.53 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (65579070..65679185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (65688244..65788359, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (65501746..65601799, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm85 Neighboring gene predicted gene, 26128 Neighboring gene predicted gene, 30786 Neighboring gene predicted gene, 40026 Neighboring gene microRNA 744 Neighboring gene predicted gene, 53682 Neighboring gene zinc finger with KRAB and SCAN domains 6 Neighboring gene dynein, axonemal, heavy chain 9 Neighboring gene predicted gene, 40027

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables JUN kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within MAPK cascade IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 4
    Names
    C-JUN N-terminal kinase kinase 1
    JNK kinase 1
    JNK-activating kinase 1
    MAP kinase kinase 4
    MAPK/ERK kinase 4
    SAPK/ERK kinase 1
    SAPK/Erk/kinase 1
    mitogen activated protein kinase kinase 4, variant 1
    NP_001303296.1
    NP_001303297.1
    NP_001303298.1
    NP_001349668.1
    NP_001349669.1
    NP_033183.1
    XP_011247335.1
    XP_030101878.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316367.1NP_001303296.1  dual specificity mitogen-activated protein kinase kinase 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AK036928, AK139777, AL662895, BY277234
      UniProtKB/TrEMBL
      Q543X6
      Conserved Domains (1) summary
      cd06616
      Location:104394
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
    2. NM_001316368.1NP_001303297.1  dual specificity mitogen-activated protein kinase kinase 4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AK036928, AL662895, BY244326, BY277234
      UniProtKB/TrEMBL
      Q543X6
      Conserved Domains (1) summary
      cl21453
      Location:1239
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001316369.1NP_001303298.1  dual specificity mitogen-activated protein kinase kinase 4 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate 5' exons compared to variant 1, that causes translation initiation from a downstream AUG. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AK036928, AL662895, BY277234, CB723868
      UniProtKB/TrEMBL
      Q543X6
      Conserved Domains (1) summary
      cl21453
      Location:1239
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001362739.1NP_001349668.1  dual specificity mitogen-activated protein kinase kinase 4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL662895, AL663069
      Conserved Domains (1) summary
      cd06616
      Location:1267
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
    5. NM_001362740.1NP_001349669.1  dual specificity mitogen-activated protein kinase kinase 4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL662895, AL663069
      Conserved Domains (1) summary
      cd06616
      Location:1267
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
    6. NM_009157.5NP_033183.1  dual specificity mitogen-activated protein kinase kinase 4 isoform b

      See identical proteins and their annotated locations for NP_033183.1

      Status: VALIDATED

      Source sequence(s)
      AK036928, AL662895, BY277234
      Consensus CDS
      CCDS24844.1
      UniProtKB/Swiss-Prot
      P47809
      UniProtKB/TrEMBL
      Q543X6
      Related
      ENSMUSP00000041282.4, ENSMUST00000046963.10
      Conserved Domains (1) summary
      cd06616
      Location:93383
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      65579070..65679185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246018.1XP_030101878.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

      Conserved Domains (1) summary
      cd06616
      Location:1267
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
    2. XM_011249033.3XP_011247335.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_011247335.1

      UniProtKB/TrEMBL
      Q8K2U0
      Conserved Domains (1) summary
      cd06616
      Location:1267
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
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