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    Map2k1 mitogen-activated protein kinase kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 26395, updated on 22-Aug-2021

    Summary

    Official Symbol
    Map2k1provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase 1provided by MGI
    Primary source
    MGI:MGI:1346866
    See related
    Ensembl:ENSMUSG00000004936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mek1; Prkm; MEKK1; MAPKK1; Prkmk1
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 50.3), cortex adult (RPKM 32.1) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map2k1 in Genome Data Viewer
    Location:
    9 C; 9 34.55 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64093051..64160887, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64185769..64253605, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64033600..64101412, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22455 Neighboring gene ribosomal protein L4 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene timeless interacting protein Neighboring gene predicted gene, 24289 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Bergmann glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi inheritance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellar cortex formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within face development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within labyrinthine layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in melanosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within placenta blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Golgi inheritance TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of early endosome to late endosome transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within trachea formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in late endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 1
    Names
    ERK activator kinase 1
    MAP kinase kinase 1
    MAPK/ERK kinase 1
    protein kinase, mitogen activated, kinase 1, p45
    NP_032953.1
    XP_006511259.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008927.4NP_032953.1  dual specificity mitogen-activated protein kinase kinase 1

      See identical proteins and their annotated locations for NP_032953.1

      Status: VALIDATED

      Source sequence(s)
      AK165894, BY698931
      Consensus CDS
      CCDS23277.1
      UniProtKB/Swiss-Prot
      P31938
      UniProtKB/TrEMBL
      Q3TMJ8
      Related
      ENSMUSP00000005066.9, ENSMUST00000005066.9
      Conserved Domains (1) summary
      cd06650
      Location:62380
      PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64093051..64160887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511196.5XP_006511259.1  dual specificity mitogen-activated protein kinase kinase 1 isoform X1

      Conserved Domains (1) summary
      cd06650
      Location:40358
      PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1
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