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    Mapkbp1 mitogen-activated protein kinase binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 26390, updated on 17-Aug-2021

    Summary

    Official Symbol
    Mapkbp1provided by MGI
    Official Full Name
    mitogen-activated protein kinase binding protein 1provided by MGI
    Primary source
    MGI:MGI:1347004
    See related
    Ensembl:ENSMUSG00000033902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jnkb; Jnkbp1; JNKBP-1; AW123212; mKIAA0596; 2810483F24Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 18.0), lung adult (RPKM 10.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Mapkbp1 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119802868..119857884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119972390..120027403)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119798435..119853139)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TYRO3 protein tyrosine kinase 3 Neighboring gene fatty acid binding protein 5, epidermal pseudogene Neighboring gene MAX gene associated Neighboring gene microRNA 7665 Neighboring gene predicted gene, 28042 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene jumonji domain containing 7 Neighboring gene spectrin beta, non-erythrocytic 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase-binding protein 1
    Names
    JNK-binding protein 1
    Jun N-terminal kinase binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355293.1NP_001342222.1  mitogen-activated protein kinase-binding protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL833774, AL954662
      Consensus CDS
      CCDS89541.1
      Related
      ENSMUSP00000155163.2, ENSMUST00000229024.2
      Conserved Domains (2) summary
      sd00039
      Location:485520
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:350732
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_011941.3NP_036071.3  mitogen-activated protein kinase-binding protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI152107, BC070449, BQ174980, CX569009
      Consensus CDS
      CCDS16612.1
      UniProtKB/Swiss-Prot
      Q6NS57
      UniProtKB/TrEMBL
      A0A0A0MQA2
      Related
      ENSMUSP00000068516.8, ENSMUST00000066058.8
      Conserved Domains (2) summary
      sd00039
      Location:479514
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:84422
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119802868..119857884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162226.1XP_036018119.1  mitogen-activated protein kinase-binding protein 1 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:485520
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:350732
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_036162225.1XP_036018118.1  mitogen-activated protein kinase-binding protein 1 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:485520
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:350732
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_030251566.2XP_030107426.1  mitogen-activated protein kinase-binding protein 1 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:479514
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:84422
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_036162227.1XP_036018120.1  mitogen-activated protein kinase-binding protein 1 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:372407
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:237619
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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