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    Esrrb estrogen related receptor, beta [ Mus musculus (house mouse) ]

    Gene ID: 26380, updated on 31-Jan-2019

    Summary

    Official Symbol
    Esrrbprovided by MGI
    Official Full Name
    estrogen related receptor, betaprovided by MGI
    Primary source
    MGI:MGI:1346832
    See related
    Ensembl:ENSMUSG00000021255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Err2; Errb; Nr3b2; Estrrb
    Expression
    Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues See more
    Orthologs

    Genomic context

    See Esrrb in Genome Data Viewer
    Location:
    12 D2; 12 40.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (86361117..86521628)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (87702067..87862578)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene G patch domain containing 2 like Neighboring gene predicted gene, 32666 Neighboring gene predicted gene, 40483 Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene vasohibin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell dedifferentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription involved in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    trophectodermal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trophectodermal cellular morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with integrator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    steroid hormone receptor ERR2
    Names
    ERR-beta
    estrogen receptor related 2
    estrogen receptor-like 2
    nuclear receptor subfamily 3 group B member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159500.1NP_001152972.1  steroid hormone receptor ERR2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK052256, AV496316, BC044858
      Consensus CDS
      CCDS49117.1
      UniProtKB/Swiss-Prot
      Q61539
      UniProtKB/TrEMBL
      E9QKA2, Q80VS1
      Related
      ENSMUSP00000112103.3, ENSMUST00000116402.9
      Conserved Domains (2) summary
      cd06946
      Location:217436
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:103198
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    2. NM_011934.4NP_036064.3  steroid hormone receptor ERR2 isoform 1

      See identical proteins and their annotated locations for NP_036064.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AK032025, AK052256, AV496316, BB642270, BC044858
      Consensus CDS
      CCDS26066.2
      UniProtKB/Swiss-Prot
      Q61539
      UniProtKB/TrEMBL
      G5E8P8, Q80VS1, Q8CCV5
      Related
      ENSMUSP00000105833.2, ENSMUST00000110204.8
      Conserved Domains (2) summary
      cd06946
      Location:233452
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:119214
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      86361117..86521628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515881.2XP_006515944.1  steroid hormone receptor ERR2 isoform X1

      Related
      ENSMUSP00000131335.1, ENSMUST00000167891.1
      Conserved Domains (2) summary
      cd06946
      Location:219438
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:105200
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    2. XM_006515883.3XP_006515946.1  steroid hormone receptor ERR2 isoform X3

      Conserved Domains (2) summary
      cd06946
      Location:52271
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:133
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. XM_006515882.2XP_006515945.1  steroid hormone receptor ERR2 isoform X2

      Conserved Domains (2) summary
      cd06946
      Location:112331
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:3393
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
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