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    Cop1 COP1, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 26374, updated on 22-Aug-2021

    Summary

    Official Symbol
    Cop1provided by MGI
    Official Full Name
    COP1, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:1347046
    See related
    Ensembl:ENSMUSG00000040782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Co; Rfwd; Rfwd2; C80879; AI316802
    Expression
    Ubiquitous expression in CNS E14 (RPKM 4.0), whole brain E14.5 (RPKM 4.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cop1 in Genome Data Viewer
    Location:
    1; 1 H1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (159059734..159182442)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (159232156..159354872)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (161162457..161277711)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930562F17 gene Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene Neighboring gene t-complex protein 11 pseudogene Neighboring gene POU domain, class 5, transcription factor 1, related sequence 1 Neighboring gene small Cajal body-specific RNA 3A Neighboring gene microRNA 1843b Neighboring gene predicted gene, 31256 Neighboring gene tenascin R Neighboring gene predicted gene, 31348

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase COP1
    Names
    E3 ubiquitin-protein ligase RFWD2
    RING finger and WD repeat domain protein 2
    RING-type E3 ubiquitin transferase RFWD2
    constitutive photomorphogenesis protein 1 homolog
    constitutive photomorphogenic protein 1
    mCOP1
    ring finger and WD repeat domain 2
    NP_001347807.1
    NP_036061.1
    XP_006496923.1
    XP_030110253.1
    XP_030110256.1
    XP_030110257.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360878.1NP_001347807.1  E3 ubiquitin-protein ligase COP1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC084287, AC113597
      Conserved Domains (4) summary
      sd00039
      Location:471508
      7WD40; WD40 repeat [structural motif]
      cd16504
      Location:134179
      RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins
      cl25539
      Location:238729
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl26688
      Location:138230
      DWNN; DWNN domain
    2. NM_011931.4NP_036061.1  E3 ubiquitin-protein ligase COP1 isoform 1

      See identical proteins and their annotated locations for NP_036061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC084287, BC082804, CJ070274
      Consensus CDS
      CCDS35745.1
      UniProtKB/Swiss-Prot
      Q9R1A8
      Related
      ENSMUSP00000076160.6, ENSMUST00000076894.11
      Conserved Domains (3) summary
      cd00200
      Location:423729
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam00097
      Location:138175
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      sd00039
      Location:475512
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      159059734..159182442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254393.2XP_030110253.1  E3 ubiquitin-protein ligase COP1 isoform X1

      Conserved Domains (2) summary
      PLN00181
      Location:3491
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:233270
      7WD40; WD40 repeat [structural motif]
    2. XM_030254396.2XP_030110256.1  E3 ubiquitin-protein ligase COP1 isoform X2

      Conserved Domains (2) summary
      PLN00181
      Location:56433
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:175212
      7WD40; WD40 repeat [structural motif]
    3. XM_006496860.4XP_006496923.1  E3 ubiquitin-protein ligase COP1 isoform X1

      Conserved Domains (2) summary
      PLN00181
      Location:3491
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:233270
      7WD40; WD40 repeat [structural motif]
    4. XM_030254397.1XP_030110257.1  E3 ubiquitin-protein ligase COP1 isoform X2

      Conserved Domains (2) summary
      PLN00181
      Location:56433
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:175212
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_004942526.1 RNA Sequence

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