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    FBXO6 F-box protein 6 [ Homo sapiens (human) ]

    Gene ID: 26270, updated on 3-Apr-2024

    Summary

    Official Symbol
    FBXO6provided by HGNC
    Official Full Name
    F-box protein 6provided by HGNC
    Primary source
    HGNC:HGNC:13585
    See related
    Ensembl:ENSG00000116663 MIM:605647; AllianceGenome:HGNC:13585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBG2; FBS2; FBX6; Fbx6b
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    1p36.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11664200..11674354)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11208255..11218422)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11724257..11734411)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11709789-11710497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11710498-11711205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 267 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:11718034-11719233 Neighboring gene F-box protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 168 Neighboring gene F-box protein 44 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11743170-11743751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11744701-11745201 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750065-11750574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750575-11751082 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11764337-11764964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11786269-11787256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808242-11808918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808919-11809595 Neighboring gene angiotensin II receptor associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with F-box protein 6 (FBXO6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum quality control compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    F-box only protein 6
    Names
    F-box protein FBG2
    F-box protein Fbx6
    F-box protein that recognizes sugar chains 2
    F-box/G-domain protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018438.6NP_060908.1  F-box only protein 6

      See identical proteins and their annotated locations for NP_060908.1

      Status: REVIEWED

      Source sequence(s)
      AF129536, AK314989, BC020880
      Consensus CDS
      CCDS133.1
      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
      UniProtKB/TrEMBL
      J3KQ72
      Related
      ENSP00000365944.4, ENST00000376753.9
      Conserved Domains (2) summary
      pfam04300
      Location:79257
      FBA; F-box associated region
      pfam12937
      Location:1358
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11664200..11674354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263448.6XP_005263505.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005263505.1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
      UniProtKB/TrEMBL
      J3KQ72
      Conserved Domains (2) summary
      pfam04300
      Location:79257
      FBA; F-box associated region
      pfam12937
      Location:1358
      F-box-like
    2. XM_005263451.6XP_005263508.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005263508.1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
      UniProtKB/TrEMBL
      J3KQ72
      Conserved Domains (2) summary
      pfam04300
      Location:79257
      FBA; F-box associated region
      pfam12937
      Location:1358
      F-box-like
    3. XM_005263449.6XP_005263506.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005263506.1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
      UniProtKB/TrEMBL
      J3KQ72
      Related
      ENSP00000388781.1, ENST00000449067.1
      Conserved Domains (2) summary
      pfam04300
      Location:79257
      FBA; F-box associated region
      pfam12937
      Location:1358
      F-box-like
    4. XM_011541232.4XP_011539534.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011539534.1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
      UniProtKB/TrEMBL
      J3KQ72
      Conserved Domains (2) summary
      pfam04300
      Location:79257
      FBA; F-box associated region
      pfam12937
      Location:1358
      F-box-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      11208255..11218422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335955.1XP_054191930.1  F-box only protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
    2. XM_054335954.1XP_054191929.1  F-box only protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
    3. XM_054335957.1XP_054191932.1  F-box only protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3
    4. XM_054335956.1XP_054191931.1  F-box only protein 6 isoform X1

      UniProtKB/Swiss-Prot
      B1AK42, B2RC88, Q9NRD1, Q9UKT3