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    SLC13A4 solute carrier family 13 member 4 [ Homo sapiens (human) ]

    Gene ID: 26266, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC13A4provided by HGNC
    Official Full Name
    solute carrier family 13 member 4provided by HGNC
    Primary source
    HGNC:HGNC:15827
    See related
    Ensembl:ENSG00000164707 MIM:604309; AllianceGenome:HGNC:15827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAS2; SUT1; SUT-1
    Summary
    Predicted to enable sodium:sulfate symporter activity. Predicted to be involved in anion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta (RPKM 28.4) and testis (RPKM 3.0) See more
    Orthologs
    NEW
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    Genomic context

    See SLC13A4 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135681231..135728186, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136988529..137035495, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (135365979..135412934, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135347996-135348520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135348521-135349045 Neighboring gene Sharpr-MPRA regulatory region 4311 Neighboring gene ribosomal protein L15 pseudogene 11 Neighboring gene RNA, U6 small nuclear 1154, pseudogene Neighboring gene short transmembrane mitochondrial protein 1 Neighboring gene uncharacterized LOC105375521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135381445-135382158 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:135382159-135382872 Neighboring gene Sharpr-MPRA regulatory region 13285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135399353-135400219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135418827-135419327 Neighboring gene family with sequence similarity 180 member A Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:135429999-135431198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135437647-135438562 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135438563-135439478 Neighboring gene uncharacterized LOC105375522

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium:sulfate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:sulfate symporter activity TAS
    Traceable Author Statement
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfate transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 13 member 4
    Names
    Na(+)/sulfate cotransporter SUT-1
    solute carrier family 13 (sodium/sulfate symporter), member 4
    solute carrier family 13 (sodium/sulfate symporters), member 4
    solute carrier family 13 (sodium/sulphate symporters), member 4
    sulphate transporter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318192.2NP_001305121.1  solute carrier family 13 member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB208809, AC091736, AF169301, BC030689
      Consensus CDS
      CCDS94210.1
      UniProtKB/TrEMBL
      A0A804HKQ4
      Related
      ENSP00000508027.1, ENST00000682651.1
      Conserved Domains (2) summary
      cd01115
      Location:38605
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
      TIGR00785
      Location:40604
      dass; anion transporter
    2. NM_012450.4NP_036582.2  solute carrier family 13 member 4 isoform 2

      See identical proteins and their annotated locations for NP_036582.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB208809, AC091736, AF169301, BC030689
      Consensus CDS
      CCDS5840.1
      UniProtKB/Swiss-Prot
      A4D1Q4, Q8N631, Q9UKG4
      Related
      ENSP00000297282.5, ENST00000354042.8
      Conserved Domains (1) summary
      cd01115
      Location:38604
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      135681231..135728186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420184.1XP_047276140.1  solute carrier family 13 member 4 isoform X2

    2. XM_011516024.4XP_011514326.1  solute carrier family 13 member 4 isoform X1

      See identical proteins and their annotated locations for XP_011514326.1

      Conserved Domains (1) summary
      cl21473
      Location:32570
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    3. XM_017011962.2XP_016867451.1  solute carrier family 13 member 4 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136988529..137035495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357863.1XP_054213838.1  solute carrier family 13 member 4 isoform X2

    2. XM_054357862.1XP_054213837.1  solute carrier family 13 member 4 isoform X1

    3. XM_054357864.1XP_054213839.1  solute carrier family 13 member 4 isoform X3