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    FBXO25 F-box protein 25 [ Homo sapiens (human) ]

    Gene ID: 26260, updated on 3-Apr-2024

    Summary

    Official Symbol
    FBXO25provided by HGNC
    Official Full Name
    F-box protein 25provided by HGNC
    Primary source
    HGNC:HGNC:13596
    See related
    Ensembl:ENSG00000147364 MIM:609098; AllianceGenome:HGNC:13596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX25
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 13.0), thyroid (RPKM 5.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FBXO25 in Genome Data Viewer
    Location:
    8p23.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (406958..477967)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (204109..275198)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (356958..427967)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:299727-300260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:328556-329056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18878 Neighboring gene family with sequence similarity 87 member A Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429047-429548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429549-430048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:436623-437436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:437437-438248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:452724-453298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:482877-483378 Neighboring gene testis development related protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:487215-487724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:486704-487214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:495813-496313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527413-527914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527915-528414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:563312-563864 Neighboring gene uncharacterized LOC124902055 Neighboring gene glutamate rich 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC20256, MGC51975

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box only protein 25
    Names
    F-box protein Fbx25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012173.4NP_036305.2  F-box only protein 25 isoform 3

      See identical proteins and their annotated locations for NP_036305.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal exons, as compared to variant 1. The encoded isoform (3) has an alternate N-terminus and lacks an internal segment in the 3' region, as compared to isoform 1.
      Source sequence(s)
      AA316216, AC083964, AF419858, AI223050, BC012143, BC050393
      Consensus CDS
      CCDS5954.1
      UniProtKB/Swiss-Prot
      Q8TCJ0
      Related
      ENSP00000341345.2, ENST00000352684.2
    2. NM_183420.2NP_904356.1  F-box only protein 25 isoform 2

      See identical proteins and their annotated locations for NP_904356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform (2) is missing an internal segment, as compared to isoform 1.
      Source sequence(s)
      AA316216, AC083964, AF419858, AI223050, BC050393
      Consensus CDS
      CCDS5952.1
      UniProtKB/TrEMBL
      B4DYA3
      Related
      ENSP00000342077.4, ENST00000350302.8
    3. NM_183421.2NP_904357.1  F-box only protein 25 isoform 1

      See identical proteins and their annotated locations for NP_904357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA316216, AC083964, AF419858, AI223050, BC050393
      Consensus CDS
      CCDS5953.1
      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3
      Related
      ENSP00000372274.2, ENST00000382824.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      406958..477967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421684.1XP_047277640.1  F-box only protein 25 isoform X2

    2. XM_017013314.2XP_016868803.1  F-box only protein 25 isoform X3

      UniProtKB/TrEMBL
      B4DYA3
    3. XM_024447125.2XP_024302893.1  F-box only protein 25 isoform X4

      UniProtKB/TrEMBL
      B4DYA3
    4. XM_017013313.3XP_016868802.1  F-box only protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3
    5. XM_011534748.4XP_011533050.1  F-box only protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011533050.1

      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
      UniProtKB/TrEMBL
      B4DYA3
    6. XM_024447123.2XP_024302891.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3
    7. XM_047421683.1XP_047277639.1  F-box only protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q6PJ83, Q7Z4V4, Q8TCJ0, Q9UKB8
    8. XM_024447124.2XP_024302892.1  F-box only protein 25 isoform X2

      UniProtKB/TrEMBL
      B4DYA3
    9. XM_047421685.1XP_047277641.1  F-box only protein 25 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      204109..275198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360277.1XP_054216252.1  F-box only protein 25 isoform X4

    2. XM_054360275.1XP_054216250.1  F-box only protein 25 isoform X2

    3. XM_054360274.1XP_054216249.1  F-box only protein 25 isoform X2

    4. XM_054360276.1XP_054216251.1  F-box only protein 25 isoform X2