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    CABYR calcium binding tyrosine phosphorylation regulated [ Homo sapiens (human) ]

    Gene ID: 26256, updated on 11-Apr-2024

    Summary

    Official Symbol
    CABYRprovided by HGNC
    Official Full Name
    calcium binding tyrosine phosphorylation regulatedprovided by HGNC
    Primary source
    HGNC:HGNC:15569
    See related
    Ensembl:ENSG00000154040 MIM:612135; AllianceGenome:HGNC:15569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT88; FSP2; CBP86; FSP-2; CABYRa; CABYRc; CABYRe; CABYRc/d
    Summary
    To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
    Expression
    Restricted expression toward testis (RPKM 117.5) See more
    Orthologs
    NEW
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    Genomic context

    See CABYR in Genome Data Viewer
    Location:
    18q11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (24139062..24161600)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (24333387..24355939)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21719026..21741564)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9361 Neighboring gene TTC39C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13169 Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13170 Neighboring gene Sharpr-MPRA regulatory region 15364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13171 Neighboring gene RNA, U5A small nuclear 6, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 452 Neighboring gene oxysterol binding protein like 1A Neighboring gene Sharpr-MPRA regulatory region 1293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21776521-21777022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21777023-21777522 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:21791138-21791312 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:21794009-21794579 Neighboring gene RNA, U6 small nuclear 435, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in epithelial cilium movement involved in extracellular fluid movement NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sperm capacitation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm principal piece ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    calcium-binding tyrosine phosphorylation-regulated protein
    Names
    calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
    calcium-binding protein 86
    cancer/testis antigen 88
    fibrousheathin II
    fibrousheathin-2
    testis tissue sperm-binding protein Li 84P
    testis-specific calcium-binding protein CBP86

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308231.2NP_001295160.1  calcium-binding tyrosine phosphorylation-regulated protein isoform f

      See identical proteins and their annotated locations for NP_001295160.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two lacks two alternate exons in the 5' coding region, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC090772, AK225858, AK301889
      Consensus CDS
      CCDS77166.1
      UniProtKB/TrEMBL
      A0A0D9SFQ2, E2ITE0
      Related
      ENSP00000486801.1, ENST00000627314.1
    2. NM_012189.4NP_036321.2  calcium-binding tyrosine phosphorylation-regulated protein isoform a

      See identical proteins and their annotated locations for NP_036321.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein isoform (a).
      Source sequence(s)
      AF088868, AK225858, AK313243, BC011996, DB055487
      Consensus CDS
      CCDS11881.1
      UniProtKB/Swiss-Prot
      B2R857, O75952, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
      UniProtKB/TrEMBL
      A0A024RC21, E2ITE0
      Related
      ENSP00000483621.1, ENST00000621648.4
      Conserved Domains (2) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
      cl26247
      Location:214414
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    3. NM_138643.3NP_619584.1  calcium-binding tyrosine phosphorylation-regulated protein isoform d

      See identical proteins and their annotated locations for NP_619584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two internal exons in the 5' region, which results in a downstream translation start codon, and has an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The resulting isoform (d) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AF295038, AK225858, BC011996, DB055487
      Consensus CDS
      CCDS11883.1
      UniProtKB/Swiss-Prot
      O75952
      Related
      ENSP00000317095.6, ENST00000327201.10
    4. NM_138644.3NP_619585.1  calcium-binding tyrosine phosphorylation-regulated protein isoform c

      See identical proteins and their annotated locations for NP_619585.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon and an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3 and 7 encode the same isoform c.
      Source sequence(s)
      AF295037, AK225858, BC011996, HY051562
      Consensus CDS
      CCDS42420.1
      UniProtKB/TrEMBL
      E2ITE2
      Related
      ENSP00000382421.1, ENST00000399499.5
      Conserved Domains (1) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    5. NM_153768.3NP_722452.1  calcium-binding tyrosine phosphorylation-regulated protein isoform b

      See identical proteins and their annotated locations for NP_722452.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) lacks an internal segment in the N-terminal region, compared to isoform a.
      Source sequence(s)
      AF329634, AK225858, AK313243, BC011996
      Consensus CDS
      CCDS11882.1
      UniProtKB/TrEMBL
      E2ITE0
      Related
      ENSP00000382404.3, ENST00000399481.6
      Conserved Domains (1) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    6. NM_153769.3NP_722453.1  calcium-binding tyrosine phosphorylation-regulated protein isoform c

      See identical proteins and their annotated locations for NP_722453.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a. Variants 3 and 7 encode the same isoform c.
      Source sequence(s)
      AK225858, BC011996, DB055487
      Consensus CDS
      CCDS42420.1
      UniProtKB/TrEMBL
      E2ITE2
      Related
      ENSP00000382419.3, ENST00000399496.8
      Conserved Domains (1) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    7. NM_153770.3NP_722454.1  calcium-binding tyrosine phosphorylation-regulated protein isoform e

      See identical proteins and their annotated locations for NP_722454.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has a alternate splice junction in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AF295039, BC011996, DB055487
      Consensus CDS
      CCDS45840.1
      UniProtKB/Swiss-Prot
      O75952
      Related
      ENSP00000399973.2, ENST00000415309.6
      Conserved Domains (1) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      24139062..24161600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258247.2XP_005258304.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

      UniProtKB/TrEMBL
      E2ITE2
      Conserved Domains (1) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    2. XM_024451160.2XP_024306928.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

      UniProtKB/Swiss-Prot
      B2R857, O75952, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
      UniProtKB/TrEMBL
      A0A024RC21, E2ITE0
      Conserved Domains (2) summary
      cd12100
      Location:1048
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
      cl26247
      Location:214414
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    3. XM_047437482.1XP_047293438.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

      UniProtKB/TrEMBL
      A0A0D9SFQ2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      24333387..24355939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318523.1XP_054174498.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

    2. XM_054318525.1XP_054174500.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

    3. XM_054318524.1XP_054174499.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

      UniProtKB/TrEMBL
      B4DXA8