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    OR2B6 olfactory receptor family 2 subfamily B member 6 [ Homo sapiens (human) ]

    Gene ID: 26212, updated on 17-Jun-2024

    Summary

    Official Symbol
    OR2B6provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily B member 6provided by HGNC
    Primary source
    HGNC:HGNC:8241
    See related
    Ensembl:ENSG00000124657 AllianceGenome:HGNC:8241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2B1; OR2B5; OR2B1P; OR2B6P; OR5-40; OR5-41; OR6-31; dJ408B20.2
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See OR2B6 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27957241..27958182)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27826892..27827833)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27925019..27925960)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily B member 2 Neighboring gene olfactory receptor family 2 subfamily W member 6 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:27934676-27934834 Neighboring gene ribosomal protein lateral stalk subunit P2 pseudogene 1 Neighboring gene olfactory receptor family 2 subfamily W member 4 pseudogene

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC120190, MGC129828

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 2B6
    Names
    hs6M1-32
    olfactory receptor 2B1
    olfactory receptor 2B5
    olfactory receptor 5-40
    olfactory receptor 6-31
    olfactory receptor OR6-4
    olfactory receptor, family 2, subfamily B, member 1 pseudogene
    olfactory receptor, family 2, subfamily B, member 5
    olfactory receptor, family 2, subfamily B, member 6 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012367.1NP_036499.1  olfactory receptor 2B6

      See identical proteins and their annotated locations for NP_036499.1

      Status: VALIDATED

      Source sequence(s)
      AL133267
      Consensus CDS
      CCDS4642.1
      UniProtKB/Swiss-Prot
      A0A126GW55, O43883, P58173, Q6IF89, Q9H5B0
      Related
      ENSP00000244623.1, ENST00000244623.1
      Conserved Domains (1) summary
      cd15947
      Location:25294
      7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      27957241..27958182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      27826892..27827833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)