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    AMD1 adenosylmethionine decarboxylase 1 [ Homo sapiens (human) ]

    Gene ID: 262, updated on 8-Jan-2023

    Summary

    Official Symbol
    AMD1provided by HGNC
    Official Full Name
    adenosylmethionine decarboxylase 1provided by HGNC
    Primary source
    HGNC:HGNC:457
    See related
    Ensembl:ENSG00000123505 MIM:180980; AllianceGenome:HGNC:457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMD; SAMDC; ADOMETDC
    Summary
    This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in prostate (RPKM 106.1), bone marrow (RPKM 38.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AMD1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (110814617..110895713)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111993221..112074322)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111135820..111216916)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 19 Neighboring gene U2 spliceosomal RNA Neighboring gene Sharpr-MPRA regulatory region 10405 Neighboring gene RNA, U6 small nuclear 1115, pseudogene Neighboring gene Sharpr-MPRA regulatory region 678 Neighboring gene small nucleolar RNA, H/ACA box 40C Neighboring gene calponin 2 pseudogene 9 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5639

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev Inhibition of S-adenosylmethionine decarboxylase, a key enzyme in polyamine biosynthesis, compromises hypusine modification and activation of eukaryotic initiation factor 5A (eIF-5A), a cellular cofactor of HIV-1 Rev, and inhibits Rev function PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ26964, DKFZp313L1234

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables adenosylmethionine decarboxylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables putrescine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in polyamine metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    S-adenosylmethionine decarboxylase proenzyme
    Names
    S-adenosylmethionine decarboxylase 1
    NP_001274143.1
    NP_001274144.1
    NP_001274145.1
    NP_001380335.1
    NP_001380336.1
    NP_001380337.1
    NP_001625.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287214.1NP_001274143.1  S-adenosylmethionine decarboxylase proenzyme isoform 3

      See identical proteins and their annotated locations for NP_001274143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AA808049, AK130474, AK300330, AK302761
      UniProtKB/TrEMBL
      A0A088AWN0, B4DZ60
      Conserved Domains (1) summary
      pfam01536
      Location:4296
      SAM_decarbox; Adenosylmethionine decarboxylase
    2. NM_001287215.2NP_001274144.1  S-adenosylmethionine decarboxylase proenzyme isoform 4

      See identical proteins and their annotated locations for NP_001274144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 7 both encode the same isoform (4).
      Source sequence(s)
      AA808049, AK130474, AK304351, Z84480
      Consensus CDS
      CCDS75505.1
      UniProtKB/TrEMBL
      B4DTR6, Q5VXN5
      Related
      ENSP00000357870.1, ENST00000368876.2
      Conserved Domains (1) summary
      pfam01536
      Location:1256
      SAM_decarbox; Adenosylmethionine decarboxylase
    3. NM_001287216.1NP_001274145.1  S-adenosylmethionine decarboxylase proenzyme isoform 5

      See identical proteins and their annotated locations for NP_001274145.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks consecutive four exons in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (5) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AA808049, AK130474, AK302761
      Consensus CDS
      CCDS75504.1
      UniProtKB/TrEMBL
      B4DZ60
      Related
      ENSP00000502112.1, ENST00000675380.1
      Conserved Domains (1) summary
      cl03253
      Location:4205
      SAM_decarbox; Adenosylmethionine decarboxylase
    4. NM_001393406.1NP_001380335.1  S-adenosylmethionine decarboxylase proenzyme isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL357515, AL365206
      Consensus CDS
      CCDS75505.1
      UniProtKB/TrEMBL
      B4DTR6
      Related
      ENSP00000357871.6, ENST00000368877.9
      Conserved Domains (1) summary
      pfam01536
      Location:1256
      SAM_decarbox; Adenosylmethionine decarboxylase
    5. NM_001393407.1NP_001380336.1  S-adenosylmethionine decarboxylase proenzyme isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform 6.
      Source sequence(s)
      AL357515, AL365206
      Conserved Domains (1) summary
      pfam01536
      Location:1208
      SAM_decarbox; Adenosylmethionine decarboxylase
    6. NM_001393408.1NP_001380337.1  S-adenosylmethionine decarboxylase proenzyme isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform 6.
      Source sequence(s)
      AL357515, AL365206
      Conserved Domains (1) summary
      pfam01536
      Location:1208
      SAM_decarbox; Adenosylmethionine decarboxylase
    7. NM_001634.6NP_001625.2  S-adenosylmethionine decarboxylase proenzyme isoform 1

      See identical proteins and their annotated locations for NP_001625.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL357515, AL365206
      Consensus CDS
      CCDS5086.1
      UniProtKB/Swiss-Prot
      P17707, Q9BWK4
      UniProtKB/TrEMBL
      A0A088AWN0, B4DZ60, Q6N0B2
      Related
      ENSP00000357880.3, ENST00000368885.8
      Conserved Domains (1) summary
      pfam01536
      Location:4325
      SAM_decarbox; Adenosylmethionine decarboxylase

    RNA

    1. NR_109768.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA808049, AK302761, AL832698
      Related
      ENST00000451850.6
    2. NR_171681.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL357515, AL365206

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      110814617..110895713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      111993221..112074322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033059.1: Suppressed sequence

      Description
      NM_001033059.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.