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    MTG2 mitochondrial ribosome associated GTPase 2 [ Homo sapiens (human) ]

    Gene ID: 26164, updated on 17-Jun-2024

    Summary

    Official Symbol
    MTG2provided by HGNC
    Official Full Name
    mitochondrial ribosome associated GTPase 2provided by HGNC
    Primary source
    HGNC:HGNC:16239
    See related
    Ensembl:ENSG00000101181 MIM:610919; AllianceGenome:HGNC:16239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ObgH1; GTPBP5; dJ1005F21.2
    Summary
    Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 3.6), skin (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MTG2 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62183028..62203568)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (63973904..63994443)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60758084..60778624)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13101 Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene Sharpr-MPRA regulatory region 1753 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:60735092-60736291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60736587-60737199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13102 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:60757942-60758126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60789379-60789879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13104 Neighboring gene histamine receptor H3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60803162-60804062 Neighboring gene uncharacterized LOC105369209

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10741, MGC29512

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitochondrial ribosome-associated GTPase 2
    Names
    GTP binding protein 5 (putative)
    GTP-binding protein 5
    protein obg homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384347.1NP_001371276.1  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL078633
      Conserved Domains (1) summary
      TIGR02729
      Location:90403
      Obg_CgtA; Obg family GTPase CgtA
    2. NM_001384348.1NP_001371277.1  mitochondrial ribosome-associated GTPase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL078633
      Conserved Domains (1) summary
      TIGR02729
      Location:72271
      Obg_CgtA; Obg family GTPase CgtA
    3. NM_015666.4NP_056481.1  mitochondrial ribosome-associated GTPase 2 isoform 2

      See identical proteins and their annotated locations for NP_056481.1

      Status: VALIDATED

      Source sequence(s)
      AL078633
      Consensus CDS
      CCDS13492.1
      UniProtKB/Swiss-Prot
      A6NDR3, B4DR85, Q96I17, Q9H4K7, Q9NVG9, Q9UFR4
      Related
      ENSP00000359859.3, ENST00000370823.8
      Conserved Domains (1) summary
      TIGR02729
      Location:72385
      Obg_CgtA; Obg family GTPase CgtA

    RNA

    1. NR_169197.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    2. NR_169198.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
      Related
      ENST00000467101.5
    3. NR_169199.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    4. NR_169200.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    5. NR_169201.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    6. NR_169202.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    7. NR_169203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    8. NR_169204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    9. NR_169205.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    10. NR_169206.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    11. NR_169207.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    12. NR_169208.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    13. NR_169209.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633
    14. NR_169210.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078633

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      62183028..62203568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440103.1XP_047296059.1  mitochondrial ribosome-associated GTPase 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDR3, B4DR85, Q96I17, Q9H4K7, Q9NVG9, Q9UFR4
    2. XM_024451869.2XP_024307637.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:88401
      Obg_CgtA; Obg family GTPase CgtA
    3. XM_017027805.2XP_016883294.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    4. XM_047440104.1XP_047296060.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      63973904..63994443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323351.1XP_054179326.1  mitochondrial ribosome-associated GTPase 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDR3, B4DR85, Q96I17, Q9H4K7, Q9NVG9, Q9UFR4
    2. XM_054323350.1XP_054179325.1  mitochondrial ribosome-associated GTPase 2 isoform X1