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    lovit loss of visual transmission [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 26067050, updated on 29-Dec-2023

    Summary

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    Official Symbol
    lovitprovided by FlyBase
    Official Full Name
    loss of visual transmissionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267429
    Locus tag
    Dmel_CG45782
    See related
    AllianceGenome:FB:FBgn0267429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40467; CG41087; CG41343; CG45782; Dmel\CG45782; GH10292; Lovit; Slc45-2
    Old locus tag
    Dmel_CG40467; Dmel_CG41087; Dmel_CG41343
    Summary
    Predicted to enable sucrose:proton symporter activity. Involved in visual perception. Located in synaptic vesicle. Is expressed in adult head and photoreceptor cell. Human ortholog(s) of this gene implicated in oculocutaneous albinism type IV and pigmentation disease. Orthologous to human SLC45A1 (solute carrier family 45 member 1) and SLC45A2 (solute carrier family 45 member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25236940..25670980, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit Neighboring gene pseudo Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45180 Neighboring gene Fatty acid synthase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_037436.4 Chromosome 3L Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. Xu Y, et al. Cell Rep, 2019 Apr 30. PMID 31042461
    2. Vesicular neurotransmitter transporters in Drosophila melanogaster. Deshpande SA, et al. Biochim Biophys Acta Biomembr, 2020 Dec 1. PMID 32305263, Free PMC Article
    3. Regulation and modulation of biogenic amine neurotransmission in Drosophila and Caenorhabditis elegans. Rosikon KD, et al. Front Physiol, 2023. PMID 36875033, Free PMC Article
    4. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article
    5. Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging. Rai M, et al. Cell Metab, 2021 Jun 1. PMID 33773104, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c25575097-25567780 mobile_element_type = transposon:gypsy{}6524
    • Loc: c25599417-25598302 mobile_element_type = transposon:1360{}6376

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sucrose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sucrose transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    loss of visual transmission
    Names
    CG45782-PA
    lovit-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      25236940..25670980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316486.1 → NP_001303415.1  loss of visual transmission [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WGX2, Q6NL41
      Conserved Domains (3) summary
      cd06174
      Location:392 → 607
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01301
      Location:66 → 580
      GPH_sucrose; GPH family sucrose/H+ symporter
      cl21472
      Location:66 → 289
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WGX2 A0A0S0WGX2

    Gene LinkOut

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    Molecular Biology Databases