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    SIPA1L1 signal induced proliferation associated 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 26037, updated on 17-Jun-2024

    Summary

    Official Symbol
    SIPA1L1provided by HGNC
    Official Full Name
    signal induced proliferation associated 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:20284
    See related
    Ensembl:ENSG00000197555 MIM:617504; AllianceGenome:HGNC:20284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E6TP1; SPAR1
    Summary
    Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SIPA1L1 in Genome Data Viewer
    Location:
    14q24.2
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (71320476..71741209)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (65525922..65946692)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71787193..72207926)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370706 Neighboring gene Sharpr-MPRA regulatory region 2320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8671 Neighboring gene uncharacterized LOC107984654 Neighboring gene Sharpr-MPRA regulatory region 5380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5896 Neighboring gene SIPA1L1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8673 Neighboring gene PDZ domain containing 11 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8674 Neighboring gene small nucleolar RNA, C/D box 56B Neighboring gene RNA, 7SL, cytoplasmic 683, pseudogene Neighboring gene uncharacterized LOC145474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72072179-72072936 Neighboring gene uncharacterized LOC124903342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72220712-72221626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72225004-72225562 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:72240666-72241865 Neighboring gene Sharpr-MPRA regulatory region 15223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72315448-72316027 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72318891-72319392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8680 Neighboring gene NANOG hESC enhancer GRCh37_chr14:72362092-72362593 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5901 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:72410437-72410648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72448203-72448816 Neighboring gene regulator of G protein signaling 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72542545-72543085 Neighboring gene uncharacterized LOC124903343 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:72621633-72622832

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37213, KIAA0440, DKFZp686G1344

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    signal-induced proliferation-associated 1-like protein 1
    Names
    SIPA1-like protein 1
    high-risk human papilloma viruses E6 oncoproteins targeted protein 1
    spine-associated RapGAP 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284245.3NP_001271174.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001271174.1

      Status: VALIDATED

      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, DA330003
      Consensus CDS
      CCDS61490.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17161771
      ZapB; Cell division protein ZapB
      pfam11881
      Location:14831728
      SPAR_C; C-terminal domain of SPAR protein
    2. NM_001284246.2NP_001271175.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001271175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004974, AF090989, AK122930
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Related
      ENSP00000351352.2, ENST00000358550.6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    3. NM_001284247.3NP_001271176.1  signal-induced proliferation-associated 1-like protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001271176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB007900, AC004900, AC004968, AL707661, BM697295, CR936651, DA034212, DA184827, DA265109, DA330003, DT219010
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17361791
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041748
      SPAR_C; C-terminal domain of SPAR protein
    4. NM_001354285.2NP_001341214.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AF090990, DA330003
      Consensus CDS
      CCDS9807.1
      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17371792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041749
      SPAR_C; C-terminal domain of SPAR protein
    5. NM_001354286.2NP_001341215.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, AK122930, DA330003
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    6. NM_001354287.2NP_001341216.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AF090989, AK122930, DA330003
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    7. NM_001354288.2NP_001341217.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AF090989, AK122930, DA330003
      Consensus CDS
      CCDS61491.1
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      ZapB; Cell division protein ZapB
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    8. NM_001354289.2NP_001341218.1  signal-induced proliferation-associated 1-like protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, DA330003
      UniProtKB/TrEMBL
      F5GYF8
      Conserved Domains (4) summary
      cd00992
      Location:459529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:135315
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:12211276
      ZapB; Cell division protein ZapB
      pfam11881
      Location:9891233
      SPAR_C; C-terminal domain of SPAR protein
    9. NM_001386936.1NP_001373865.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476
      Consensus CDS
      CCDS61490.1
      UniProtKB/TrEMBL
      A6H8W6
      Related
      ENSP00000370630.3, ENST00000381232.8
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17161771
      ZapB; Cell division protein ZapB
      pfam11881
      Location:14831728
      SPAR_C; C-terminal domain of SPAR protein
    10. NM_015556.4NP_056371.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AC004900, AC004968, AC004974, AC005476, AC005994, AF090990, DA330003
      Consensus CDS
      CCDS9807.1
      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17371792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041749
      SPAR_C; C-terminal domain of SPAR protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      71320476..71741209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431217.1XP_047287173.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    2. XM_047431229.1XP_047287185.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    3. XM_047431218.1XP_047287174.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    4. XM_047431243.1XP_047287199.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    5. XM_047431251.1XP_047287207.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    6. XM_047431209.1XP_047287165.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    7. XM_047431239.1XP_047287195.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    8. XM_047431245.1XP_047287201.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    9. XM_047431253.1XP_047287209.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8
    10. XM_047431219.1XP_047287175.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    11. XM_047431238.1XP_047287194.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    12. XM_047431247.1XP_047287203.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    13. XM_047431246.1XP_047287202.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    14. XM_024449529.2XP_024305297.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17371792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041749
      SPAR_C; C-terminal domain of SPAR protein
    15. XM_017021198.2XP_016876687.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    16. XM_047431249.1XP_047287205.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    17. XM_047431252.1XP_047287208.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8
    18. XM_047431223.1XP_047287179.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    19. XM_047431248.1XP_047287204.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    20. XM_047431241.1XP_047287197.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    21. XM_011536632.2XP_011534934.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011534934.1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17371792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041749
      SPAR_C; C-terminal domain of SPAR protein
    22. XM_047431250.1XP_047287206.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    23. XM_047431220.1XP_047287176.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    24. XM_047431224.1XP_047287180.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    25. XM_047431242.1XP_047287198.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    26. XM_047431231.1XP_047287187.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    27. XM_047431227.1XP_047287183.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    28. XM_047431215.1XP_047287171.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    29. XM_047431240.1XP_047287196.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    30. XM_047431213.1XP_047287169.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    31. XM_047431214.1XP_047287170.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    32. XM_047431212.1XP_047287168.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    33. XM_047431226.1XP_047287182.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    34. XM_047431211.1XP_047287167.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    35. XM_047431222.1XP_047287178.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    36. XM_047431244.1XP_047287200.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    37. XM_047431232.1XP_047287188.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6
    38. XM_047431233.1XP_047287189.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A6H8W6
    39. XM_047431234.1XP_047287190.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A6H8W6
    40. XM_047431235.1XP_047287191.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6H8W6
    41. XM_047431236.1XP_047287192.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A6H8W6
    42. XM_047431237.1XP_047287193.1  signal-induced proliferation-associated 1-like protein 1 isoform X7

      UniProtKB/TrEMBL
      A6H8W6
    43. XM_047431228.1XP_047287184.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    44. XM_047431225.1XP_047287181.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    45. XM_047431216.1XP_047287172.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    46. XM_005267516.5XP_005267573.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005267573.1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
      Related
      ENSP00000450832.1, ENST00000555818.5
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17371792
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041749
      SPAR_C; C-terminal domain of SPAR protein
    47. XM_017021185.2XP_016876674.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17361791
      ZapB; Cell division protein ZapB
      pfam11881
      Location:15041748
      SPAR_C; C-terminal domain of SPAR protein
    48. XM_011536638.3XP_011534940.1  signal-induced proliferation-associated 1-like protein 1 isoform X11

      UniProtKB/TrEMBL
      F5GYF8
      Related
      ENSP00000440682.1, ENST00000537413.5
      Conserved Domains (4) summary
      cd00992
      Location:428498
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:104284
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:12121267
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:9791224
      SPAR_C; C-terminal domain of SPAR protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      65525922..65946692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375796.1XP_054231771.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    2. XM_054375805.1XP_054231780.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    3. XM_054375797.1XP_054231772.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    4. XM_054375795.1XP_054231770.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    5. XM_054375802.1XP_054231777.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    6. XM_054375803.1XP_054231778.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    7. XM_054375794.1XP_054231769.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    8. XM_054375801.1XP_054231776.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    9. XM_054375825.1XP_054231800.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    10. XM_054375791.1XP_054231766.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    11. XM_054375811.1XP_054231786.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6
    12. XM_054375813.1XP_054231788.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A6H8W6
    13. XM_054375814.1XP_054231789.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A6H8W6
    14. XM_054375815.1XP_054231790.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6H8W6
    15. XM_054375816.1XP_054231791.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A6H8W6
    16. XM_054375817.1XP_054231792.1  signal-induced proliferation-associated 1-like protein 1 isoform X7

      UniProtKB/TrEMBL
      A6H8W6
    17. XM_054375808.1XP_054231783.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    18. XM_054375804.1XP_054231779.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    19. XM_054375809.1XP_054231784.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    20. XM_054375823.1XP_054231798.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    21. XM_054375833.1XP_054231808.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    22. XM_054375793.1XP_054231768.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    23. XM_054375820.1XP_054231795.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    24. XM_054375826.1XP_054231801.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    25. XM_054375835.1XP_054231810.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8
    26. XM_054375798.1XP_054231773.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    27. XM_054375819.1XP_054231794.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    28. XM_054375828.1XP_054231803.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    29. XM_054375827.1XP_054231802.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    30. XM_054375807.1XP_054231782.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    31. XM_054375818.1XP_054231793.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    32. XM_054375830.1XP_054231805.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    33. XM_054375834.1XP_054231809.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F5GYF8
    34. XM_054375821.1XP_054231796.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    35. XM_054375799.1XP_054231774.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    36. XM_054375800.1XP_054231775.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    37. XM_054375810.1XP_054231785.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    38. XM_054375829.1XP_054231804.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    39. XM_054375832.1XP_054231807.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    40. XM_054375822.1XP_054231797.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    41. XM_054375824.1XP_054231799.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

      UniProtKB/TrEMBL
      F5GYF8
    42. XM_054375831.1XP_054231806.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      F5GYF8
    43. XM_054375806.1XP_054231781.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    44. XM_054375792.1XP_054231767.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
      UniProtKB/TrEMBL
      A6H8W6
    45. XM_054375812.1XP_054231787.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H8W6
    46. XM_054375836.1XP_054231811.1  signal-induced proliferation-associated 1-like protein 1 isoform X11

      UniProtKB/TrEMBL
      F5GYF8