Format

Send to:

Choose Destination
    • Showing Current items.

    Nav3 neuron navigator 3 [ Mus musculus (house mouse) ]

    Gene ID: 260315, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nav3provided by MGI
    Official Full Name
    neuron navigator 3provided by MGI
    Primary source
    MGI:MGI:2183703
    See related
    Ensembl:ENSMUSG00000020181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POM; unc53H; POMFIL1; unc53H3; Pomfil1p; mKIAA0938; 4732483H20Rik; 9630020C08Rik
    Expression
    Biased expression in CNS E18 (RPKM 6.2), cortex adult (RPKM 6.1) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nav3 in Genome Data Viewer
    Location:
    10; 10 D1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (109517121..110292148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (109681260..110455722, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (109120495..109437275, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23041 Neighboring gene predicted gene, 40757 Neighboring gene predicted gene, 47340 Neighboring gene RIKEN cDNA 9230102K24 gene Neighboring gene predicted gene, 36751

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuron navigator 3
    Names
    pore membrane and/or filament-interacting-like protein 1
    steerin 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081035.2NP_001074504.1  neuron navigator 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC100120, AC122011, AC129336
      Consensus CDS
      CCDS36054.1
      UniProtKB/TrEMBL
      E9QMF5
      Related
      ENSMUSP00000032719.8, ENSMUST00000032719.15
      Conserved Domains (5) summary
      cd00009
      Location:20332113
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:20302150
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:81182
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15898
      Location:17751838
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl21455
      Location:20172047
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001368815.1NP_001355744.1  neuron navigator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC100120, AC122011, AC129336
      Conserved Domains (6) summary
      smart00382
      Location:20232143
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9791294
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:81182
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04211
      Location:15731649
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:204582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15898
      Location:17681831
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      109517121..110292148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155787.1XP_036011680.1  neuron navigator 3 isoform X4

      Conserved Domains (5) summary
      smart00382
      Location:19732093
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9221237
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:15191779
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:147525
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:24126
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
    2. XM_006513680.4XP_006513743.1  neuron navigator 3 isoform X8

      Conserved Domains (7) summary
      smart00382
      Location:18531973
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9791297
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:13991659
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04211
      Location:13961472
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:204582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00307
      Location:81182
      CH; Calponin homology (CH) domain
      pfam15898
      Location:16071661
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    3. XM_006513679.4XP_006513742.1  neuron navigator 3 isoform X7

      Conserved Domains (7) summary
      smart00382
      Location:18671987
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9791311
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:14131673
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04211
      Location:14101486
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:204582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00307
      Location:81182
      CH; Calponin homology (CH) domain
      pfam15898
      Location:16211675
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    4. XM_006513676.4XP_006513739.1  neuron navigator 3 isoform X1

      Conserved Domains (7) summary
      smart00382
      Location:20162136
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9791294
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:15621822
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04211
      Location:15591635
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:204582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00307
      Location:81182
      CH; Calponin homology (CH) domain
      pfam15898
      Location:17701824
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    5. XM_006513677.4XP_006513740.1  neuron navigator 3 isoform X3

      Conserved Domains (6) summary
      smart00382
      Location:20072127
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9561271
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:15531813
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04211
      Location:15501626
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:262559
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00307
      Location:81182
      CH; Calponin homology (CH) domain
    6. XM_017313948.3XP_017169437.1  neuron navigator 3 isoform X10

      Related
      ENSMUSP00000158790.2, ENSMUST00000238286.2
      Conserved Domains (6) summary
      smart00382
      Location:15151635
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:478793
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02169
      Location:10501321
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      TIGR04211
      Location:10581134
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:659996
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15898
      Location:12691323
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    7. XM_006513681.5XP_006513744.1  neuron navigator 3 isoform X9

      Conserved Domains (6) summary
      smart00382
      Location:15291649
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:478793
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02169
      Location:10641335
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      TIGR04211
      Location:10721148
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:6591010
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15898
      Location:12831337
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    8. XM_036155788.1XP_036011681.1  neuron navigator 3 isoform X5

      Conserved Domains (5) summary
      smart00382
      Location:19502070
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:8991214
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:14961756
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:205502
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:24126
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
    9. XM_017313946.3XP_017169435.1  neuron navigator 3 isoform X4

      Related
      ENSMUSP00000159239.2, ENSMUST00000239301.2
      Conserved Domains (5) summary
      smart00382
      Location:19732093
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9221237
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:15191779
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:147525
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:24126
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
    10. XM_017313945.2XP_017169434.1  neuron navigator 3 isoform X2

      Conserved Domains (6) summary
      smart00382
      Location:20092129
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:9791294
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04211
      Location:15591635
      SH3_and_anchor; SH3 domain protein
      pfam05109
      Location:204582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00307
      Location:81182
      CH; Calponin homology (CH) domain
      pfam15898
      Location:17631817
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    11. XM_036155789.1XP_036011682.1  neuron navigator 3 isoform X6

      Conserved Domains (5) summary
      smart00382
      Location:18932013
      AAA; ATPases associated with a variety of cellular activities
      PHA03307
      Location:8421157
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:14391699
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:67445
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl00030
      Location:146
      CH_SF; calponin homology (CH) domain superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177797.2: Suppressed sequence

      Description
      NM_177797.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Support Center