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    Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 260302, updated on 16-Aug-2021

    Summary

    Official Symbol
    Gga3provided by MGI
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 3provided by MGI
    Primary source
    MGI:MGI:2384159
    See related
    Ensembl:ENSMUSG00000020740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0154; C230037M19Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.1), spleen adult (RPKM 15.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gga3 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115475081..115495501, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115584255..115604517, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115445569..115465220, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene small ubiquitin-like modifier 2 Neighboring gene nucleoporin 85 Neighboring gene predicted gene, 25364 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-binding protein GGA3
    Names
    golgi-localized, gamma ear-containing, ARF-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252067.1NP_001238996.1  ADP-ribosylation factor-binding protein GGA3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK082327, BC056424, BY268727
      Consensus CDS
      CCDS56817.1
      UniProtKB/TrEMBL
      A2A9W7
      Related
      ENSMUSP00000102117.4, ENSMUST00000106508.10
      Conserved Domains (3) summary
      smart00809
      Location:518632
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:8146
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14240
      Location:213299
      GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
    2. NM_173048.3NP_766636.2  ADP-ribosylation factor-binding protein GGA3 isoform 1

      See identical proteins and their annotated locations for NP_766636.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132183, BC056424, BY268727
      Consensus CDS
      CCDS25641.1
      UniProtKB/Swiss-Prot
      Q8BMI3
      Related
      ENSMUSP00000019135.8, ENSMUST00000019135.14
      Conserved Domains (3) summary
      smart00809
      Location:596710
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:8146
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14240
      Location:213299
      GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115475081..115495501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533365.5XP_006533428.1  ADP-ribosylation factor-binding protein GGA3 isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:334669
      PHA03247; large tegument protein UL36; Provisional
      cd14240
      Location:213299
      GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
      cd17008
      Location:6146
      VHS_GGA3; VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA3
      pfam02883
      Location:593682
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam18308
      Location:169207
      GGA_N-GAT; GGA N-GAT domain
    2. XM_011249031.3XP_011247333.1  ADP-ribosylation factor-binding protein GGA3 isoform X2

      Conserved Domains (4) summary
      smart00809
      Location:460574
      Alpha_adaptinC2; Adaptin C-terminal domain
      PHA03247
      Location:198533
      PHA03247; large tegument protein UL36; Provisional
      cd14240
      Location:77163
      GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3
      pfam18308
      Location:3371
      GGA_N-GAT; GGA N-GAT domain
    3. XM_011249032.1XP_011247334.1  ADP-ribosylation factor-binding protein GGA3 isoform X3

      Conserved Domains (3) summary
      smart00809
      Location:366480
      Alpha_adaptinC2; Adaptin C-terminal domain
      PHA03247
      Location:104439
      PHA03247; large tegument protein UL36; Provisional
      cd14240
      Location:169
      GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3

    RNA

    1. XR_388465.5 RNA Sequence

      Related
      ENSMUST00000156173.8
    2. XR_004936965.1 RNA Sequence

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