U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MOXD1 monooxygenase DBH like 1 [ Homo sapiens (human) ]

    Gene ID: 26002, updated on 5-Mar-2024

    Summary

    Official Symbol
    MOXD1provided by HGNC
    Official Full Name
    monooxygenase DBH like 1provided by HGNC
    Primary source
    HGNC:HGNC:21063
    See related
    Ensembl:ENSG00000079931 MIM:609000; AllianceGenome:HGNC:21063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOX; PRO5780; dJ248E1.1
    Summary
    Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Part of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in endometrium (RPKM 34.3), adrenal (RPKM 21.6) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MOXD1 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132296055..132401475, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133491085..133596511, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132617194..132722614, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132453077-132454276 Neighboring gene long intergenic non-protein coding RNA 1013 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 36 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:132675510-132676709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17549 Neighboring gene Sharpr-MPRA regulatory region 15532 Neighboring gene syntaxin 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25071 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:132833503-132834004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25072 Neighboring gene ribosomal protein L21 pseudogene 66

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of monooxygenase, DBH-like 1 (MOXD1) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564G202

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dopamine beta-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dopamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in norepinephrine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in octopamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DBH-like monooxygenase protein 1
    Names
    dopamine-oxygenase
    monooxygenase X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015529.4NP_056344.2  DBH-like monooxygenase protein 1 precursor

      See identical proteins and their annotated locations for NP_056344.2

      Status: VALIDATED

      Source sequence(s)
      AJ420565, AK074879, AY007239, BC018756
      Consensus CDS
      CCDS5152.2
      UniProtKB/Swiss-Prot
      Q5THU6, Q6UVY6, Q8NC97, Q8WV49, Q9H4M6, Q9Y4U3
      Related
      ENSP00000356940.3, ENST00000367963.8
      Conserved Domains (3) summary
      cd09631
      Location:29165
      DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
      pfam01082
      Location:186312
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:335482
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132296055..132401475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010714.3XP_016866203.1  DBH-like monooxygenase protein 1 isoform X1

    2. XM_047418622.1XP_047274578.1  DBH-like monooxygenase protein 1 isoform X3

    3. XM_047418621.1XP_047274577.1  DBH-like monooxygenase protein 1 isoform X2

      Related
      ENSP00000336998.3, ENST00000336749.3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133491085..133596511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355127.1XP_054211102.1  DBH-like monooxygenase protein 1 isoform X1

    2. XM_054355129.1XP_054211104.1  DBH-like monooxygenase protein 1 isoform X3

    3. XM_054355128.1XP_054211103.1  DBH-like monooxygenase protein 1 isoform X2